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Pack Size | Price | Availability | Quantity |
---|---|---|---|
5 mg | $55 | In Stock | |
10 mg | $89 | In Stock | |
25 mg | $178 | In Stock | |
50 mg | Inquiry | In Stock |
Description | 8-Bromo-cGMP sodium is a PKG activator, a membrane-permeable analog of cGMP. 8-Bromo-cGMP sodium has pain-relieving and vasodilatory effects, significantly inhibits Ca2+ macroscopic currents, and inhibits high K+-stimulated insulin release. |
In vitro | 8-Bromo-cGMP sodium (1 µM-0.1 mM) can inhibit acetylcholine-induced increases in intracellular calcium concentrations.[1] 8-Bromo-cGMP sodium (1-100 μM; 16 h) induces the synthesis of HO-1 protein in a concentration-dependent fashion.[2] 8-Bromo-cGMP sodium (1-100 μM; 8 h) increases the resistance of LLC-PK1 cells to CsA toxicity in concentration-dependently.[2] |
In vivo | 8-Bromo-cGMP sodium (0.3, 1, 3 nM; intrathecal administration; 10 min before the test; male ICR mice) significantly increases the tail-flick latency in Vincristine-treated mice to the level observed in vehicle-treated naive mice in dose-dependently.[3] 8-Bromo-cGMP sodium (10 mg/kg; iv; single dose) results in vasodilator responses in WT littermates and eNOS-Tg mice in C57BL/6 background (19-35 g).[4] |
Molecular Weight | 447.09 |
Formula | C10H11BrN5NaO7P |
Cas No. | 51116-01-9 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | |||||||||||||||||||||||||||||||||||
Solubility Information | H2O: 90.0 mg/mL (201.8 mM) | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
H2O
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