Powder: -20°C for 3 years | In solvent: -80°C for 1 year
9-Phenanthrol is inhibitor of the transient receptor potential melastatin 4 (TRPM) channel, a Ca2+ -activated non-selective cation channel.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
25 mg | In stock | $ 41.00 | |
50 mg | In stock | $ 53.00 | |
100 mg | In stock | $ 76.00 | |
200 mg | In stock | $ 111.00 |
Description | 9-Phenanthrol is inhibitor of the transient receptor potential melastatin 4 (TRPM) channel, a Ca2+ -activated non-selective cation channel. |
In vitro | In addition, 9-phenanthrol, lacking the chemical groups necessary for CFTR activation, also reversibly inhibited TRPM4 with a similar IC(50). Channel inhibition was voltage independent. The IC(50) determined in the whole-cell and inside-out experiments were similar, suggesting a direct effect of the molecule. However, 9-phenanthrol was ineffective on TRPM5, the most closely related channel within the TRP protein family. We identify 9-phenanthrol as a TRPM4 inhibitor, without effects on TRPM5. It could be valuable in investigating the physiological functions of TRPM4, as distinct from those of TRPM5[1]. |
Molecular Weight | 194.23 |
Formula | C14H10O |
CAS No. | 484-17-3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 19 mg/mL (97.82 mM), Sonication is recommended.
Ethanol: 9 mg/mL (46.34 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. More
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9-Phenanthrol 484-17-3 Membrane transporter/Ion channel TRP/TRPV Channel ischemia-reperfusion injury inhibit TRPM4 NSC-50554 9Phenanthrol Inhibitor NSC 50554 TRP Channel 9-Hydroxyphenanthrene Transient receptor potential channels 9 Phenanthrol NSC50554 inhibitor