Powder: -20°C for 3 years | In solvent: -80°C for 1 year
ACY-1083 is a selective and brain-penetrating HDAC6 inhibitor (IC50: 3 nM) and effectively reverses chemotherapy-induced peripheral neuropathy.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 155.00 | |
5 mg | In stock | $ 328.00 | |
10 mg | In stock | $ 559.00 | |
25 mg | In stock | $ 883.00 | |
50 mg | In stock | $ 1,230.00 | |
100 mg | In stock | $ 1,660.00 | |
500 mg | In stock | $ 3,330.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 363.00 |
Description | ACY-1083 is a selective and brain-penetrating HDAC6 inhibitor (IC50: 3 nM) and effectively reverses chemotherapy-induced peripheral neuropathy. |
Targets&IC50 | HDAC6:3 nM |
In vitro | ACY-1083 (30 and 300 nM) dose-dependently improves cell viability[2]. |
In vivo | In C57BL/6J mice, ACY-1083 (10 mg/kg; i.p.) effectively relieves Cisplatin-induced mechanical allodynia. In adult male SD rats, ACY-1083 (3 mg/kg; orally) reverses Paclitaxel-induced mechanical allodynia. ACY-1083(5 mg/kg; i.p.) shows a Cmax of 936 ng/mL, a half-life (T1/2) of 3.5h, and a biologically active plasma exposure of 8 hours[1]. |
Molecular Weight | 348.35 |
Formula | C17H18F2N4O2 |
CAS No. | 1708113-43-2 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 180 mg/mL (516.7 mM), Sonification is recommended.
You can also refer to dose conversion for different animals. More
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ACY-1083 1708113-43-2 Chromatin/Epigenetic DNA Damage/DNA Repair HDAC ACY1083 ACY 1083 inhibitor inhibit