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AFMK

Catalog No. T41345 CAS 52450-38-1

Synonyms: Formyl-N-acetyl-5-methoxykynurenamine, Acetyl-N-formyl-5-methoxykynurenamine

AFMK (Formyl-N-acetyl-5-methoxykynurenamine) is an active metabolite of Melatonin with antioxidant and free radical scavenging activity. AFMK is a modulator of apoptosis and improves the anti-tumor effect of Gemcitabine in PANC-1 cells.

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AFMK, CAS 52450-38-1

Pack Size	Availability	Price/USD
1 mg	In stock	$ 58.00
2 mg	In stock	$ 89.00
5 mg	In stock	$ 128.00
10 mg	In stock	$ 198.00
25 mg	In stock	$ 323.00
50 mg	In stock	$ 479.00
100 mg	In stock	$ 686.00
500 mg	In stock	$ 1,480.00
1 mL * 10 mM (in DMSO)	In stock	$ 136.00

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Purity: 99.89%

Biological Description

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Description	AFMK (Formyl-N-acetyl-5-methoxykynurenamine) is an active metabolite of Melatonin with antioxidant and free radical scavenging activity. AFMK is a modulator of apoptosis and improves the anti-tumor effect of Gemcitabine in PANC-1 cells.
In vitro	In PANC-1 cell, AFMK in combination with Gemcitabine increases the inhibition of the production of HSP70 from 0.47 (Gemcitabine alone) to 0.13 (10 nM AFMK), 0.08 (0.1 nM AFMK) and 0.01 (0.001 nM AFMK)[1]. AFMK pretreatment significantly inhibits DNA damage and shows a very high hydroxyl radical scavenging potential with an IC50 of 338.08 nM[3].
In vivo	In male C57BL mice, AFMK (10 mg/kg; i.p.) significantly reverses radiation-induced decline in the total antioxidant capacity of plasma. Pretreatment of AFMK shows a significantly lower value of comet tail length and % DNA in tail[3].

Synonyms	Formyl-N-acetyl-5-methoxykynurenamine, Acetyl-N-formyl-5-methoxykynurenamine
Molecular Weight	264.28
Formula	C13H16N2O4
CAS No.	52450-38-1

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 50 mg/mL (189.19 mM)

References and Literature

1. Anna Leja-Szpak, et al. Melatonin and its metabolite N1-acetyl-N2-formyl-5-methoxykynuramine (afmk) enhance chemosensitivity to gemcitabine in pancreatic carcinoma cells (PANC-1). Pharmacol Rep. 2018 Dec;70(6):1079-1088. 2. Annia Galano, et al. On the free radical scavenging activities of melatonin's metabolites, AFMK and AMK. J Pineal Res. 2013 Apr;54(3):245-57. 3. Kailash Manda, et al. AFMK, a melatonin metabolite, attenuates X-ray-induced oxidative damage to DNA, proteins and lipids in mice. J Pineal Res. 2007 Apr;42(4):386-93.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Active Compound Library Antioxidant Compound Library Bioactive Compound Library Anti-Cancer Compound Library Bioactive Compounds Library Max

Related Products

Related compounds with same targets

Palomid 529 Mocetinostat Tomentosin GSK-J4 Gemcitabine elaidate PRIMA-1 GSK-3β inhibitor 3 Lomustine

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Keywords

AFMK 52450-38-1 Apoptosis Metabolism oxidation-reduction Endogenous Metabolite Free radical scavengers Antioxidant Formyl-N-acetyl-5-methoxykynurenamine Acetyl-N-formyl-5-methoxykynurenamine inhibitor inhibit

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