keep away from moisture
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
AICAR phosphate (Acadesine phosphate) is an AMPK activator and inhibitor of autophagy, YAP, and mitophagy, as well as an adenosine analog that regulates glucose and lipid metabolism, and inhibits the production of pro-inflammatory cytokines and iNOS.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
25 mg | In stock | $ 42.00 |
Description | AICAR phosphate (Acadesine phosphate) is an AMPK activator and inhibitor of autophagy, YAP, and mitophagy, as well as an adenosine analog that regulates glucose and lipid metabolism, and inhibits the production of pro-inflammatory cytokines and iNOS. |
In vitro | HepG2 cells were treated with different concentrations of AICAR phosphate (0.1-1.0 mM) for 12, 24, and 48 hours, respectively. The final results demonstrated that AICAR phosphate reduced the expression of the insulin receptor protein[1]. |
In vivo | Male 5-week-old ZDF rats were either subcutaneously injected with a single dose of AICAR phosphate (0.5 mg/g) or subjected to a single bout of treadmill running. The results showed that compared to untreated control ZDF rats, both the exercise group and the rats receiving AICAR phosphate injection exhibited significantly increased AMPK-α2 activity in the white gastrocnemius muscle[2]. |
Synonyms | AICA Riboside phosphate, Acadesine phosphate |
Molecular Weight | N/A |
Formula | C9H14N4O5.xH3O4P |
CAS No. | 681006-28-0 |
keep away from moisture
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 75 mg/mL (210.54 mM)
H2O: 80 mg/mL (224.57 mM), Sonification is recommeded
You can also refer to dose conversion for different animals. More
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
AICAR phosphate 681006-28-0 Autophagy Chromatin/Epigenetic Immunology/Inflammation PI3K/Akt/mTOR signaling Stem Cells Mitophagy NOS YAP AMPK AICA Riboside phosphate Acadesine phosphate inhibitor inhibit