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AICAR phosphate

Catalog No. T14149   CAS 681006-28-0
Synonyms: AICA Riboside phosphate, Acadesine phosphate

AICAR phosphate (Acadesine phosphate) is an AMPK activator and inhibitor of autophagy, YAP, and mitophagy, as well as an adenosine analog that regulates glucose and lipid metabolism, and inhibits the production of pro-inflammatory cytokines and iNOS.

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AICAR phosphate Chemical Structure
AICAR phosphate, CAS 681006-28-0
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Biological Description
Chemical Properties
Storage & Solubility Information
Description AICAR phosphate (Acadesine phosphate) is an AMPK activator and inhibitor of autophagy, YAP, and mitophagy, as well as an adenosine analog that regulates glucose and lipid metabolism, and inhibits the production of pro-inflammatory cytokines and iNOS.
In vitro HepG2 cells were treated with different concentrations of AICAR phosphate (0.1-1.0 mM) for 12, 24, and 48 hours, respectively. The final results demonstrated that AICAR phosphate reduced the expression of the insulin receptor protein[1].
In vivo Male 5-week-old ZDF rats were either subcutaneously injected with a single dose of AICAR phosphate (0.5 mg/g) or subjected to a single bout of treadmill running. The results showed that compared to untreated control ZDF rats, both the exercise group and the rats receiving AICAR phosphate injection exhibited significantly increased AMPK-α2 activity in the white gastrocnemius muscle[2].
Synonyms AICA Riboside phosphate, Acadesine phosphate
Molecular Weight N/A
Formula C9H14N4O5.xH3O4P
CAS No. 681006-28-0

Storage

keep away from moisture

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 75 mg/mL (210.54 mM)

H2O: 80 mg/mL (224.57 mM), Sonification is recommeded

TargetMolReferences and Literature

1. Nakamaru K, et al. AICAR, an activator of AMP-activated protein kinase, down-regulates the IR expression in HepG2 cells. Biochem Biophys Res Commun. 2005 Mar 11;328(2):449-54 2. Pold R, et al. Long-term AICAR administration and exercise prevents diabetes in ZDF rats.Diabetes. 2005 Apr;54(4):928-34. 3. Drake JC, et al. AICAR treatment for 14 days normalizes obesity-induced dysregulation of TORC1 signaling and translational capacity in fasted skeletal muscle. Am J Physiol Regul Integr Comp Physiol. 2010 Dec;299(6):R1546-54. 4. Pold R, et al. Long-term AICAR administration and exercise prevents diabetes in ZDF rats.Diabetes. 2005 Apr;54(4):928-34.

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Keywords

AICAR phosphate 681006-28-0 Autophagy Chromatin/Epigenetic Immunology/Inflammation PI3K/Akt/mTOR signaling Stem Cells Mitophagy NOS YAP AMPK AICA Riboside phosphate Acadesine phosphate inhibitor inhibit

 

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