Powder: -20°C for 3 years
In solvent: -80°C for 2 years
AM251 is a effective CB1 receptor antagonist (IC50/Ki: 8 /7.49 nM) that displays 306-fold selectivity over CB2 receptors; also effective GPR55 agonist (EC50: 39 nM).
Description | AM251 is a effective CB1 receptor antagonist (IC50/Ki: 8 /7.49 nM) that displays 306-fold selectivity over CB2 receptors; also effective GPR55 agonist (EC50: 39 nM). |
Targets&IC50 | GPR55:39 nM, CB1:8 nM |
Kinase Assay | Macrophages are seeded (2×106/well) in 12-well culture plates. AM-251 or SR144528 are added from 4 mM stock solutions prepared in DMSO, 1h prior to the addition of 7-ketocholesterol (7KC) from a 2 mg/mL ethanol stock solution. Controls are adjusted to receive equivalent volumes of DMSO and ethanol. After 16 h, caspase-3 activity is determined. All treatments are done in triplicate and the data presented as the mean RFLU/mg protein±SD[3]. |
Molecular Weight | 555.24 |
Formula | C22H21Cl2IN4O |
CAS No. | 183232-66-8 |
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
Ethanol: 13.9 mg/mL (25 mM)
DMSO: 55.5 mg/mL (100 mM)
( < 1 mg/ml refers to the product slightly soluble or insoluble )
You can also refer to dose conversion for different animals. More
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
AM251 183232-66-8 Endocrinology/Hormones GPCR/G Protein Cannabinoid Receptor GPR Inhibitor AM 251 inhibit AM-251 inhibitor