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Acarbose

Catalog No. T0247 CAS 56180-94-0

Synonyms: BAY g 5421

Acarbose (BAY g 5421) is an inhibitor of α-Glucosidases with antihyperglycemic activity.

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Acarbose, CAS 56180-94-0

Pack Size	Availability	Price/USD
100 mg	In stock	$ 35.00
200 mg	In stock	$ 50.00
1 g	In stock	$ 79.00

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Purity: 99.89%

Purity: 99.88%

Purity: 99.62%

Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Acarbose (BAY g 5421) is an inhibitor of α-Glucosidases with antihyperglycemic activity.
In vitro	Acarbose binds to and inhibits α-glucosidase, an enteric enzyme found in the brush border of the small intestines that hydrolyzes oligosaccharides and disaccharides into glucose and other monosaccharides. In addition, acarbose inhibits pancreatic α-amylase which hydrolyzes complex starches to oligosaccharides in the small intestines.
Cell Research	Cell viability is determined using the MTT assay. Cells are seeded in 24-well culture plates at a density of 2×104 cells/well, incubated for 48 h, treated with acarbose at varying concentrations (0.5, 1.0, 2.0, 3.0, and 5.0 μM) for 24 h; or pre-treated with TNF-α (20 ng/mL) for either 24 h or 48 h to evaluate the dose-dependent effects of acarbose on VSMC growth and viability, cultured with 0.5 mg/mL MTT at 37°C in a humidified atmosphere of 5% CO2 for another 4 h, and solubilized with isopropanol. The viable cell number varies directly with the concentration of formazan product measured spectrophotometrically at 563 nm.

Synonyms	BAY g 5421
Molecular Weight	645.6
Formula	C25H43NO18
CAS No.	56180-94-0

Storage

keep away from direct sunlight

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 64.5 mg/mL (100 mM)

H2O: 64.5 mg/mL (100 mM)

References and Literature

1. Martin AE, et al. Am J Health Syst Pharm, 1996, 53(19), 2277-2290. 2. Wang PY, et al. Hepatology,1999, 29(1), 161-165. 3. Okada K, et al. Hepatol Res,2009, 39(5), 490-500. 4. Russell JC, et al. Metabolism,1993, 42(2), 218-223. 5. Azuma K, et al. Biochem Biophys Res Commun,2006, 345(2), 688-693. 6. Chan KC, et al. Pleiotropic effects of acarbose on atherosclerosis development in rabbits are mediated via upregulating AMPK signals. Sci Rep. 2016 Dec 7;6:3864 7. Chen X Q, Lin L G, Zhao J, et al. Isolation, Structural Elucidation, and α-Glucosidase Inhibitory Activities of Triterpenoid Lactones and Their Relevant Biogenetic Constituents from Ganoderma resinaceum[J]. Molecules. 2018 Jun 8;23(6). pii: E1391.

Citations

1. Zhan Z T, Liu L, Cheng M Z, et al. The Effects of 6 Common Antidiabetic Drugs on Anti-PD1 Immune Checkpoint Inhibitor in Tumor Treatment. Journal of Immunology Research. 2022 2. Chen X Q, Lin L G, Zhao J, et al. Isolation, Structural Elucidation, and α-Glucosidase Inhibitory Activities of Triterpenoid Lactones and Their Relevant Biogenetic Constituents from Ganoderma resinaceum. Molecules. 2018 Jun 8;23(6). pii: E1391. 3. Zhou L, Tian M, Zhang B, et al.Lysosome targeting fluorescent probe for NAAA imaging and its applications in the drug development for anti-inflammatory.International Journal of Biological Macromolecules.2024: 130307.

Related compound libraries

This product is contained In the following compound libraries：

Kinase Inhibitor Library Microbial Natural Product Library FDA-Approved Kinase Inhibitor Library Inhibitor Library Drug Repurposing Compound Library Anti-COVID-19 Compound Library Natural Product Library for HTS Anti-Metabolism Disease Compound Library FDA-Approved Drug Library Anti-Obesity Compound Library

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Keywords

Acarbose 56180-94-0 Metabolism Glucosidase mellitus oral antihyperglycemic insulin anti-diabetes BAY g5421 Inhibitor BAY g-5421 BAY g 5421 inhibit inhibitor

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