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Adefovir dipivoxil

Catalog No. T1675 CAS 142340-99-6

Synonyms: Hepsera, GS 0840, Preveon

Adefovir dipivoxil (GS 0840) is a dipivoxil formulation of adefovir, a nucleoside reverse transcriptase inhibitor analog of adenosine with activity against hepatitis B virus (HBV), herpes virus, and human immunodeficiency virus (HIV).

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Adefovir dipivoxil, CAS 142340-99-6

Pack Size	Availability	Price/USD
25 mg	In stock	$ 33.00
50 mg	In stock	$ 45.00
100 mg	In stock	$ 61.00
200 mg	In stock	$ 97.00
500 mg	In stock	$ 231.00
1 mL * 10 mM (in DMSO)	In stock	$ 48.00

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Purity: 100%

Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Adefovir dipivoxil (GS 0840) is a dipivoxil formulation of adefovir, a nucleoside reverse transcriptase inhibitor analog of adenosine with activity against hepatitis B virus (HBV), herpes virus, and human immunodeficiency virus (HIV).
In vitro	Compared to the placebo control group with 5.3 log10 GE/mL, Adefovir Dipivoxil significantly reduced serum HBV DNA levels in transgenic mice to 3.5 log10 genome equivalents (GE) per mL, indicating a marked suppression of the hepatitis B virus. In the liver, Adefovir Dipivoxil's antiviral activity peaked on day 10, achieving hepatitis B virus inhibition endpoints at a dose of 1.0 mg/kg/day. Furthermore, Adefovir Dipivoxil decreased liver HBV DNA to <0.1 picograms of hepatitis B virus per total DNA (picograms/mg) in each transgenic mouse.
In vivo	In the duck HBV (DHBV) model, Adefovir dipivoxil, when used in combination with other nucleoside analogs (Lamivudine, Entecavir, Emtricitabine [FTC], and Telbivudine [L-dT]), exhibits superior antiviral effects compared to monotherapy. Adefovir dipivoxil effectively inhibits viral CCC DNA both in vitro and in vivo within the same model. Notably, Adefovir retains significant anti-HBV activity soon after being introduced to cells. Its use in conjunction with Lamivudine, FTC, or L-dT demonstrates cumulative effects, while synergy is observed when combined with Entecavir or Tenofovir. Additionally, Adefovir dipivoxil suppresses the activity of the polymerase by inhibiting the transcription of the pre-genomic RNA. The dosage of Adefovir dipivoxil is correlated with its ability to suppress the release of the virus in culture supernatants and the synthesis of viral DNA within cells.

Synonyms	Hepsera, GS 0840, Preveon
Molecular Weight	501.47
Formula	C20H32N5O8P
CAS No.	142340-99-6

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: < 1 mg/mL (insoluble or slightly soluble)

DMSO: 93 mg/mL (185.5 mM)

Ethanol: 93 mg/mL (185.5 mM)

References and Literature

1. Julander JG, et al. Antiviral Res, 2002, 55(1), 27-40. 2. Delmas J, et al. Antimicrob Agents Chemother, 2002, 46(2), 425-433. 3. Delaney WE 4th, et al. Antimicrob Agents Chemother, 2004, 48(10), 3702-3710. 4. Ying, et al. J Viral Hepat, 2000, 7(1), 79-83. 5. Chen X, et al. J Natl Cancer Inst, 2003, 95(14), 1053-1061. 6. Thieulent C, Hue E, Sutton G, et al. Identification of antiviral compounds against equid herpesvirus-1 using real-time cell assay screening: efficacy of decitabine and valganciclovir alone or in combination[J]. Antiviral Research. 2020: 104931

Citations

1. Thieulent C, Hue E, Sutton G, et al. Identification of antiviral compounds against equid herpesvirus-1 using real-time cell assay screening: efficacy of decitabine and valganciclovir alone or in combination. Antiviral Research. 2020: 104931 2. Dsouza L, Pant A, Offei S, et al.Antiviral activities of two nucleos (t) ide analogs against vaccinia, mpox, and cowpox viruses in primary human fibroblasts.Antiviral Research.2023: 105651.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Traditional Chinese Medicine Monomer Library Drug Repurposing Compound Library EMA Approved Drug Library Orally Active Compound Library Anti-Viral Compound Library Nucleotide Compound Library ReFRAME Related Library Approved Drug Library NO PAINS Compound Library

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

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Keywords

Adefovir dipivoxil 142340-99-6 Microbiology/Virology Others Reverse Transcriptase HBV inhibit Endogenous Metabolite infection GS0840 GS-0840 Hepsera Hepatitis B virus analogue nucleotide prodrug GS 0840 oral Inhibitor Preveon inhibitor

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