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Aftin-4

Catalog No. T4364 CAS 866893-90-5

Synonyms: Aftin4, Aftin 4

Aftin-4, an amyloid forty-two inducer, activates γ-secretase, promoting the generation of amyloid-β-1-42 (Aβ1-42) from amyloid-β protein precursor. Aftin-4 increased Aβ-1-42, but not Aβ-1-40 in mouse hipppocampus, accompanied by learning deficits and mitochondrial ultrastructural changes similar to those found in the brains of patients with AD. Aftin-4 can thus be used to induce a rapid, acute Alzheimer's disease-like toxicity in the rodent brain.

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Aftin-4, CAS 866893-90-5

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Purity: 98%

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Description

Animal Research

Brains of 4-mo-old C57BL/6 wild-type mice were dissected and mechanically disassociated in HBSS with a tissue homogenizer. Aliquots from each mouse were incubated with DMSO and two concentrations of Aftin-4 at 37°C for 3 h. Liquefied brains were sonicated and centrifuged at 13,000 rpm for 15 min. WB analysis was performed using CT695 antibody for soluble Aβ-CTF. They are for reference only.

Synonyms	Aftin4, Aftin 4
Molecular Weight	368.485
Formula	C20H28N6O
CAS No.	866893-90-5

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 25 mg/mL

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Bettayeb K, etal. Small-molecule inducers of Aβ-42 peptide production share a common mechanism of action.[J]. Faseb Journal Official Publication of the Federation of American Societies for Experimental Biology, 2012, 26(12):5115-23. 2. Meunier J, etal. Brain toxicity and inflammation induced in vivo in mice by the amyloid-β forty-two inducer aftin-4, a roscovitine derivative[J]. Journal of Alzheimers Disease Jad, 2015, 44(2):507-24. 3. Hochard A, etal. Aftins increase amyloid-β42, lower amyloid-β38, and do not alter amyloid-β40 extracellular production in vitro: toward a chemical model of Alzheimer's disease [J]. Journal of Alzheimers Disease Jad, 2013, 35(1):107-120.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Compound Library Inhibitor Library Mitochondria-Targeted Compound Library Anti-Alzheimer's Disease Compound Library Neuronal Signaling Compound Library Target-Focused Phenotypic Screening Library Anti-Neurodegenerative Disease Compound Library Bioactive Compound Library

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Keywords

Aftin-4 866893-90-5 蛋白酶体干细胞神经科学 Beta Amyloid Gamma-secretase Aftin4 β-amyloid peptide inhibit Abeta Amyloid-β Inhibitor Aftin 4 inhibitor

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