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Aftin-4

Catalog No. T4364 CAS 866893-90-5

Synonyms: Aftin 4, Aftin4

Aftin-4, an amyloid forty-two inducer, activates γ-secretase, promoting the generation of amyloid-β-1-42 (Aβ1-42) from amyloid-β protein precursor. Aftin-4(Aftin4) increased Aβ-1-42, but not Aβ-1-40 in mouse hipppocampus, accompanied by learning deficits and mitochondrial ultrastructural changes similar to those found in the brains of patients with AD. Aftin-4(Aftin4) can thus be used to induce a rapid, acute Alzheimer's disease-like toxicity in the rodent brain.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

Aftin-4, CAS 866893-90-5

Pack Size	Availability	Price/USD
1 mg	In stock	$ 41.00
2 mg	In stock	$ 59.00
5 mg	In stock	$ 122.00
10 mg	In stock	$ 197.00
25 mg	In stock	$ 397.00
50 mg	In stock	$ 589.00
100 mg	In stock	$ 843.00
1 mL * 10 mM (in DMSO)	In stock	$ 97.00

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Purity: 99.03%

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Description

Animal Research

Brains of 4-mo-old C57BL/6 wild-type mice were dissected and mechanically disassociated in HBSS with a tissue homogenizer. Aliquots from each mouse were incubated with DMSO and two concentrations of Aftin-4 at 37°C for 3 h. Liquefied brains were sonicated and centrifuged at 13,000 rpm for 15 min. WB analysis was performed using CT695 antibody for soluble Aβ-CTF. They are for reference only.

Synonyms	Aftin 4, Aftin4
Molecular Weight	368.48
Formula	C20H28N6O
CAS No.	866893-90-5

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 55 mg/mL (149.26 mM)

References and Literature

1. Bettayeb K, etal. Small-molecule inducers of Aβ-42 peptide production share a common mechanism of action.[J]. Faseb Journal Official Publication of the Federation of American Societies for Experimental Biology, 2012, 26(12):5115-23. 2. Meunier J, etal. Brain toxicity and inflammation induced in vivo in mice by the amyloid-β forty-two inducer aftin-4, a roscovitine derivative[J]. Journal of Alzheimers Disease Jad, 2015, 44(2):507-24. 3. Hochard A, etal. Aftins increase amyloid-β42, lower amyloid-β38, and do not alter amyloid-β40 extracellular production in vitro: toward a chemical model of Alzheimer's disease [J]. Journal of Alzheimers Disease Jad, 2013, 35(1):107-120.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Neurodegenerative Disease Compound Library NO PAINS Compound Library Anti-Alzheimer's Disease Compound Library Bioactive Compounds Library Max Neuronal Signaling Compound Library Stem Cell Differentiation Compound Library Target-Focused Phenotypic Screening Library Bioactive Compound Library

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Keywords

Aftin-4 866893-90-5 Neuroscience Proteases/Proteasome Stem Cells Beta Amyloid Gamma-secretase Aftin 4 β-amyloid peptide inhibit Abeta Amyloid-β Aftin4 Inhibitor inhibitor

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