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Alendronate sodium hydrate

Alendronate sodium hydrate
Alendronate sodium hydrate (MK 217) is a nitrogen-containing bisphosphonate, which is an effective inhibitor of bone resorption. It is utilized for the treatment and prevention of osteoporosis.
Catalog No. T6373Cas No. 121268-17-5
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Purity:99.78%
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Alendronate sodium hydrate

Purity: 99.78%
Catalog No. T6373Alias MK 217, G-704650 Adronat, G-704650, Fosamax, Alendronate sodium trihydrate, AlendronateCas No. 121268-17-5

Alendronate sodium hydrate (MK 217) is a nitrogen-containing bisphosphonate, which is an effective inhibitor of bone resorption. It is utilized for the treatment and prevention of osteoporosis.
With extensive experience in compound synthesis, we can provide rapid custom synthesis services for this product according to your research needs.
Pack SizePriceAvailabilityQuantity
50 mg$40In Stock
100 mg$48In Stock
200 mg$54In Stock
500 mg$85In Stock
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Product Introduction

Bioactivity
Description
Alendronate sodium hydrate (MK 217) is a nitrogen-containing bisphosphonate, which is an effective inhibitor of bone resorption. It is utilized for the treatment and prevention of osteoporosis.
Targets&IC50
FPPS:460 nM.
In vitro
In mice, pretreatment with 0.1 mg/kg of Alendronate one to two times a week, in combination with 10-50 mg/kg of paclitaxel, effectively inhibits the growth of PC-3 ML tumors in bone marrow and soft tissue, significantly extending survival times to 4-5 weeks. In rats, Alendronate exacerbates indomethacin-induced gastric damage and delays the healing of gastric ulcers. In rabbits, Alendronate causes gastric erosion and increases the incidence and area of indomethacin-induced antral ulcers.
In vivo
Sodium alendronate primarily inhibits the rate-limiting step in the cholesterol biosynthesis pathway within osteoclasts. Lowering the levels of farnesyl pyrophosphate interferes with protein prenylation and concurrently inhibits the biosynthesis pathway of isoprenoids. Additionally, sodium alendronate acts to suppress sterol in osteoclasts.
Kinase Assay
Rat liver cytosol is prepared from a separate piece of liver from rat. Assays are carried out in a total volume of 0.1 mL containing 10 mg of cytosolic protein, and components according to Rilling. All reaction components (except IPP) are mixed and kept on ice for 15 min. Reactions are initiated by the addition of [14C]IPP and incubation at 37°C. Reactions are stopped after 5 min by addition of 0.4 mL MeOH/HCl (4/1, by vol.) and the samples are incubated a further 15 min to hydrolyze the allylic pyrophosphates to petroleum ether-extractable products. Following addition of 0.5 mL water and 1 mL petroleum ether, 50% of the upper (petroleum ether-extractable) phase is taken for liquid scintillation analysis. Preliminary experiments indicated that the reaction is linear with time and protein under these conditions, and no more than 10% of the substrate is consumed.
AliasMK 217, G-704650 Adronat, G-704650, Fosamax, Alendronate sodium trihydrate, Alendronate
Chemical Properties
Molecular Weight325.12
FormulaC4H12NO7P2·3H2O·Na
Cas No.121268-17-5
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
H2O: 28.57 mg/mL (87.88 mM), Sonication is recommended.
DMSO: Slightly soluble
Solution Preparation Table
H2O
1mg5mg10mg50mg
1 mM3.0758 mL15.3789 mL30.7579 mL153.7894 mL
5 mM0.6152 mL3.0758 mL6.1516 mL30.7579 mL
10 mM0.3076 mL1.5379 mL3.0758 mL15.3789 mL
20 mM0.1538 mL0.7689 mL1.5379 mL7.6895 mL
50 mM0.0615 mL0.3076 mL0.6152 mL3.0758 mL

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