keep away from direct sunlight
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Amentoflavone (3',8''-Biapigenin), as a potent inhibitor of CYP3A4 and CYP2C9, can interact with many other medications. CYP3A4 and CYP2C9 are proteins used for drug metabolism in the body. Amentoflavone also is an inhibitor of human cathepsin B. It has antimalarial activity in trials significant affinities towards the Delta-1, kappa opioid receptors (as an antagonist) and binds to benzodiazepine receptors. Amentoflavone may be a potential lead for a new type of anti-inflammatory agents having the dual inhibitory activity of group II phospholipase A2 and cyclooxygenase. Amentoflavone and quercetin differentially exerted suppression of PGE2 biosynthesis via downregulation of COX-2/iNOS expression.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 30.00 | |
5 mg | In stock | $ 61.00 | |
10 mg | In stock | $ 98.00 | |
25 mg | In stock | $ 166.00 | |
50 mg | In stock | $ 292.00 | |
100 mg | In stock | $ 446.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 72.00 |
Description | Amentoflavone (3',8''-Biapigenin), as a potent inhibitor of CYP3A4 and CYP2C9, can interact with many other medications. CYP3A4 and CYP2C9 are proteins used for drug metabolism in the body. Amentoflavone also is an inhibitor of human cathepsin B. It has antimalarial activity in trials significant affinities towards the Delta-1, kappa opioid receptors (as an antagonist) and binds to benzodiazepine receptors. Amentoflavone may be a potential lead for a new type of anti-inflammatory agents having the dual inhibitory activity of group II phospholipase A2 and cyclooxygenase. Amentoflavone and quercetin differentially exerted suppression of PGE2 biosynthesis via downregulation of COX-2/iNOS expression. |
Source |
Synonyms | Didemethyl-ginkgetin, Amenthoflavone, 3',8''-Biapigenin |
Molecular Weight | 538.46 |
Formula | C30H18O10 |
CAS No. | 1617-53-4 |
keep away from direct sunlight
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 34 mg/mL(63.14 mM), Sonification is recommended
Chloroform, Dichloromethane, Ethyl Acetate: Soluble
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Amentoflavone 1617-53-4 Apoptosis Endocrinology/Hormones GPCR/G Protein Immunology/Inflammation Metabolism Microbiology/Virology Neuroscience NF-Κb Phospholipase P450 RSV Antifungal Antibacterial COX Reactive Oxygen Species Opioid Receptor Gamma-aminobutyric acid Receptor Inhibitor inhibit orally active U-87 MG cells C-FLIP Didemethyl-ginkgetin γ-Aminobutyric acid Receptor Fungal MCL1 Respiratory syncytial virus anti-inflammatory Amenthoflavone GABA Receptor 3',8''-Biapigenin NF-?B antibacterial Bacterial inhibitor