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Arjunolic acid

Catalog No. TN1403 CAS 465-00-9

Arjunolic acid has Antioxidant, anti-inflammatory, antinociceptive and anticholinesterasic (AChE and BuChE) activities, it may as promising targets for the development of innovative multi-functional medicines for Alzheimer desease treatment.

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Arjunolic acid, CAS 465-00-9

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description

Arjunolic acid has antioxidant, anti-inflammatory, antinociceptive and anticholinesterasic (AChE and BuChE) activities, it may as promising targets for the development of innovative multi-functional medicines for Alzheimer desease treatment.

In vitro

This review highlights the beneficial role of Arjunolic acid, a naturally occurring chiral triterpenoid saponin, in various organ pathophysiology and the underlying mechanism of its protective action. Studies on the biochemistry and pharmacology suggest the potential use of Arjunolic acid as a novel promising therapeutic strategy. WHAT THE READERS WILL GAIN: The multifunctional therapeutic application of Arjunolic acid has already been documented by its various biological functions including antioxidant, anti-fungal, anti-bacterial, anticholinesterase, antitumor, antiasthmatic, wound healing and insect growth inhibitor activities. The scientific basis behind its therapeutic application as a cardioprotective agent in traditional medicine is justified by its ability to prevent myocardial necrosis and apoptosis, platelet aggregation, coagulation and lowering of blood pressure, heart rate, as well as cholesterol levels. Its antioxidant property coupled with metal chelating property (by its two hydroxyl groups) protects different organs from metal and drug-induced organ pathophysiology. Arjunolic acid also plays a beneficial role in the pathogenesis of diabetes and its associated complications. The mechanism of cytoprotection of Arjunolic acid, at least in part, results from the detoxification of reactive oxygen species (ROS) produced in the respective pathophysiology. In addition to its other biological functions, it also possesses vibrant insecticidal properties and it has the potential to be used as a structural molecular framework for the design of molecular receptors in the general area of supramolecular chemistry and nanochemistry. Esters of Arjunolic acid function as organogelators which has wide application in designing thermochromic switches and sensor devices. Arjunolic acid derived crown ether is an attractive candidate for the design of molecular receptors, biomimetics and supramolecular systems capable of performing some biological functions[1]

Molecular Weight	488.7
Formula	C30H48O5
CAS No.	465-00-9

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 100 mg/mL (204.62 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Arjunolic acid: a new multifunctional therapeutic promise of alternative medicine.Biochimie. 2013 Jun;95(6):1098-109.

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Keywords

Arjunolic acid 465-00-9 Apoptosis Immunology/Inflammation MAPK Metabolism Neuroscience NF-Κb IL Receptor Reactive Oxygen Species TNF AChE JNK hepatocyte injury hyperglycemia Inhibitor type 1 diabetes antimicrobial antioxidant Antidiabetic antibacterial inhibit Symplocos lancifolia reactive oxygen inhibitor

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