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Aurintricarboxylic acid

Catalog No. T8333 CAS 4431-00-9

Synonyms: ATA, NSC-4056, NSC4056, NSC 4056

Aurintricarboxylic acid (NSC-4056) is a strong inhibitor of topoisomerases and other nucleases. It is a potent inhibitor of ribonuclease and topoisomerase II by preventing the binding of the nucleic acid to the enzyme.

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Aurintricarboxylic acid Chemical Structure

Aurintricarboxylic acid, CAS 4431-00-9

Pack Size	Availability	Price/USD
50 mg	In stock	$ 30.00
100 mg	In stock	$ 43.00
200 mg	In stock	$ 61.00
500 mg	In stock	$ 97.00
1 mL * 10 mM (in DMSO)	In stock	$ 48.00

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Purity: 95%

Biological Description

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Description	Aurintricarboxylic acid (NSC-4056) is a strong inhibitor of topoisomerases and other nucleases. It is a potent inhibitor of ribonuclease and topoisomerase II by preventing the binding of the nucleic acid to the enzyme.
Targets&IC50	P2X1 (rat):8.6 nM, MicroRNA:0.47 μM, P2X3 (rat):72.9 nM
In vitro	Aurintricarboxylic acid (ATA) is a known Stp1 inhibitor with an IC50 of 1.03 μM[1].

Synonyms	ATA, NSC-4056, NSC4056, NSC 4056
Molecular Weight	422.34
Formula	C22H14O9
CAS No.	4431-00-9

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 125 mg/mL (295.97 mM), Sonification is recommended.

References and Literature

1. Liu T T , Yang T , Gao M N , et al. The inhibitory mechanism of aurintricarboxylic acid targeting serine/threonine phosphatase Stp1 in Staphylococcus aureus: insights from molecular dynamics simulations[J]. Acta Pharmacologica Sinica, 2019. 2. Zhan P, Li Z, Liu X. Cosalane and its analogues: a unique class of anti-HIV agents. Mini Rev Med Chem. 2010 Sep;10(10):966-76. Review. PubMed PMID: 20540707. 3. De Clercq E. The next ten stories on antiviral drug discovery (part E): advents, advances, and adventures. Med Res Rev. 2011 Jan;31(1):118-60. doi: 10.1002/med.20179. Review. PubMed PMID: 19844936. 4. Clemetson KJ, Clemetson JM. Platelet GPIb complex as a target for anti-thrombotic drug development. Thromb Haemost. 2008 Mar;99(3):473-9. doi: 10.1160/TH07-12-0718. Review. PubMed PMID: 18327394.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Ion Channel Inhibitor Library Anti-Cancer Compound Library Anti-Viral Compound Library Bioactive Compounds Library Max NO PAINS Compound Library Apoptosis Compound Library Neuronal Signaling Compound Library Anti-Infection Compound Library Human Metabolite Library

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Aurintricarboxylic acid 4431-00-9 Apoptosis DNA Damage/DNA Repair Membrane transporter/Ion channel Microbiology/Virology Neuroscience Topoisomerase Influenza Virus P2X Receptor receptor ATA NSC-4056 P2XRs glioblastoma anti-influenza miRNA chronic NSC4056 MicroRNA family pain ATP-gated TWEAK neurotransmission inhibit P2X TWEAK-Fn14 Fn14 neuropathic Inhibitor sensory cough NSC 4056 inhibitor

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