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BAY 41-2272

Catalog No. T6775   CAS 256376-24-6

BAY 41-2272 is a direct and NO-independent soluble guanylate cyclase (sGC) stimulator.

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BAY 41-2272, CAS 256376-24-6
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Purity: 98%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description BAY 41-2272 is a direct and NO-independent soluble guanylate cyclase (sGC) stimulator.
In vitro In vitro, BAY 41-2272 results in concentration dependent relaxation of human and rabbit cavernosum with EC50 of 489.1 nM and 406.3 nM, respectively. [3]
In vivo In female spontaneously hypertensive rats, BAY 41-2272 (10 mg/kg, p.o.) shows antiplatelet effect, strongly decreases blood pressure and increases survival. [2] In C. albicans-infected mice, BAY 41-2272 (10 mg/kg, i.p.) markedly increases macrophage-dependent cell influx to the peritoneum in addition to macrophage functions, and reduces the death rate. [4] In db/db-/- type II diabetic and obese mice, BAY 41-2272 improves impaired corpus cavernosum (CC) relaxation. [5]
Molecular Weight 360.396
Formula C20H17FN6
CAS No. 256376-24-6


Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 36 mg/mL (100 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Becker EM, et al. BMC Pharmacol. 2001, 1, 13. 2. Stasch JP, et al. Nature. 2001, 410(6825), 212-215. 3. Kalsi JS, et al. J Urol. 2003, 169(2), 761-766. 4. Soeiro-Pereira PV, et al. Mem Inst Oswaldo Cruz. 2015, 110(1), 75-85. 5. Nunes KP, et al. J Pharmacol Exp Ther. 2015, 353(2), 330-339. 6. Tuttle TR, et al. The cyclic GMP/protein kinase G pathway as a therapeutic target in head and neck squamous cell carcinoma. Cancer Lett. 2016 Jan 28;370(2):279-85.

Related compound libraries

This product is contained In the following compound libraries:
Preclinical Compound Library Anti-Cardiovascular Disease Compound Library Anti-Infection Compound Library Bioactive Compound Library

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Plecanatide Nelociguat Nitroprusside disodium dihydrate Methylene Blue MCUF-651 LY83583 ODQ Runcaciguat

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BAY 41-2272 256376-24-6 G蛋白偶联受体 Guanylate cyclase Inhibitor inhibit Guanylate Cyclase BAY 41 2272 BAY 412272 inhibitor