Powder: -20°C for 3 years
In solvent: -80°C for 2 years
BAY 41-2272 is a direct and NO-independent soluble guanylate cyclase (sGC) stimulator.
Description | BAY 41-2272 is a direct and NO-independent soluble guanylate cyclase (sGC) stimulator. |
In vitro | In vitro, BAY 41-2272 results in concentration dependent relaxation of human and rabbit cavernosum with EC50 of 489.1 nM and 406.3 nM, respectively. [3] |
In vivo | In female spontaneously hypertensive rats, BAY 41-2272 (10 mg/kg, p.o.) shows antiplatelet effect, strongly decreases blood pressure and increases survival. [2] In C. albicans-infected mice, BAY 41-2272 (10 mg/kg, i.p.) markedly increases macrophage-dependent cell influx to the peritoneum in addition to macrophage functions, and reduces the death rate. [4] In db/db-/- type II diabetic and obese mice, BAY 41-2272 improves impaired corpus cavernosum (CC) relaxation. [5] |
Molecular Weight | 360.396 |
Formula | C20H17FN6 |
CAS No. | 256376-24-6 |
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
DMSO: 36 mg/mL (100 mM)
( < 1 mg/ml refers to the product slightly soluble or insoluble )
You can also refer to dose conversion for different animals. More
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BAY 41-2272 256376-24-6 G蛋白偶联受体 Guanylate cyclase Inhibitor inhibit Guanylate Cyclase BAY 41 2272 BAY 412272 inhibitor