Powder: -20°C for 3 years | In solvent: -80°C for 1 year
BAY 41-2272 is a direct and NO-independent soluble guanylate cyclase (sGC) stimulator.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 34.00 | |
2 mg | In stock | $ 47.00 | |
5 mg | In stock | $ 75.00 | |
10 mg | In stock | $ 135.00 | |
25 mg | In stock | $ 287.00 | |
50 mg | In stock | $ 457.00 | |
100 mg | In stock | $ 673.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 75.00 |
Description | BAY 41-2272 is a direct and NO-independent soluble guanylate cyclase (sGC) stimulator. |
In vitro | In vitro, BAY 41-2272 results in concentration dependent relaxation of human and rabbit cavernosum with EC50 of 489.1 nM and 406.3 nM, respectively. [3] |
In vivo | In female spontaneously hypertensive rats, BAY 41-2272 (10 mg/kg, p.o.) shows antiplatelet effect, strongly decreases blood pressure and increases survival. [2] In C. albicans-infected mice, BAY 41-2272 (10 mg/kg, i.p.) markedly increases macrophage-dependent cell influx to the peritoneum in addition to macrophage functions, and reduces the death rate. [4] In db/db-/- type II diabetic and obese mice, BAY 41-2272 improves impaired corpus cavernosum (CC) relaxation. [5] |
Molecular Weight | 360.39 |
Formula | C20H17FN6 |
CAS No. | 256376-24-6 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 36 mg/mL (100 mM)
You can also refer to dose conversion for different animals. More
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BAY 41-2272 256376-24-6 GPCR/G Protein Guanylate cyclase Inhibitor inhibit Guanylate Cyclase BAY 41 2272 BAY 412272 inhibitor