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BAY-598
BAY 598 is a potent and selective competitive inhibitor of SMYD2 lysine methyltransferase, IC50 values are 27 and 58 nM for biochemical and cellular activity assays, respectively.
Catalog No. T7403Cas No. 1906919-67-2
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Purity:99.18%
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BAY-598
Catalog No. T7403Cas No. 1906919-67-2
BAY 598 is a potent and selective competitive inhibitor of SMYD2 lysine methyltransferase, IC50 values are 27 and 58 nM for biochemical and cellular activity assays, respectively.
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose. | Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $52 | In Stock | |
| 5 mg | $107 | In Stock | |
| 10 mg | $169 | In Stock | |
| 25 mg | $263 | In Stock | |
| 50 mg | $446 | In Stock | |
| 100 mg | $719 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $123 | In Stock |
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | BAY 598 is a potent and selective competitive inhibitor of SMYD2 lysine methyltransferase, IC50 values are 27 and 58 nM for biochemical and cellular activity assays, respectively. |
| Targets&IC50 | SMYD2:27 nM |
| In vitro | BAY-598 treatment blocked in vitro methylation of MAPKAPK3 by SMYD2 but had no activity against the SMYD2-related KMT SMYD3, which methylated its substrate, MAP3K2, irrespective of the presence of BAY-598.?BAY-598 treatment reduced the growth of Kras;p53 mutant PDAC cells after 9 d in culture but had little impact on the growth of Kras;p53;Smyd2 mutant cells , further supporting the specificity of this small molecule inhibitor of SMYD2 as well as a role for SMYD2 in promoting the growth of PDAC cells[1]. |
| Molecular Weight | 525.34 |
| Formula | C22H20Cl2F2N6O3 |
| Cas No. | 1906919-67-2 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 125 mg/mL (237.94 mM) | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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