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BAY-598
🥰Excellent
Catalog No. T7403Cas No. 1906919-67-2
BAY 598 is a potent and selective competitive inhibitor of SMYD2 lysine methyltransferase, IC50 values are 27 and 58 nM for biochemical and cellular activity assays, respectively.
BAY-598
🥰Excellent
Purity: 99.18%
Catalog No. T7403Cas No. 1906919-67-2
BAY 598 is a potent and selective competitive inhibitor of SMYD2 lysine methyltransferase, IC50 values are 27 and 58 nM for biochemical and cellular activity assays, respectively.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $43 | In Stock | |
| 5 mg | $88 | In Stock | |
| 10 mg | $142 | In Stock | |
| 25 mg | $263 | In Stock | |
| 50 mg | $428 | In Stock | |
| 100 mg | $645 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $98 | In Stock |
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CitedSelect Batch
Purity:99.18%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | BAY 598 is a potent and selective competitive inhibitor of SMYD2 lysine methyltransferase, IC50 values are 27 and 58 nM for biochemical and cellular activity assays, respectively. |
| Targets&IC50 | SMYD2:27 nM |
| In vitro | METHODS: PDAC cells SW1990 and MIA PaCa2 were treated with BAY-598 (10 µM) and doxorubicin (1 µM) for 48 h. Cell viability was determined by MTT assay. RESULTS: PDAC cells were highly sensitive to acute treatment with the low-dose combination of doxorubicin and BAY-598. [1] |
| In vivo | METHODS: To detect antitumor activity in vivo, BAY-598 (50 mg/kg once daily) and gemcitabine (100 mg/kg every three days) were administered intraperitoneally to NSG mice bearing SW1990 xenografts for 27 days. RESULTS: The combination of gemcitabine and BAY-598 attenuated the growth of SW1990 xenografts compared to monotherapy. [1] METHODS: To assay anti-tumor activity in vivo, BAY-598 (10-100 mg/kg, PEG 400/water 8:2) was administered orally to BALB/c nude mice bearing KYSE-150 xenografts once daily for three days. RESULTS: BAY-598 was able to inhibit SMYD2 methylation activity in tumor cells in vivo. [2] |
| Molecular Weight | 525.34 |
| Formula | C22H20Cl2F2N6O3 |
| Cas No. | 1906919-67-2 |
| Smiles | CCN([C@H]1CN(N=C1c1ccc(Cl)c(Cl)c1)C(\NC#N)=N\c1cccc(OC(F)F)c1)C(=O)CO |
| Relative Density. | 1.46 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 125 mg/mL (237.94 mM) | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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