Powder: -20°C for 3 years | In solvent: -80°C for 1 year
BRD6688 is a selective HDAC2 inhibitor that acts by enhancing the learning and memory processes
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 121.00 | |
5 mg | In stock | $ 289.00 | |
10 mg | In stock | $ 512.00 | |
25 mg | In stock | $ 833.00 | |
50 mg | In stock | $ 1,150.00 | |
100 mg | In stock | $ 1,550.00 | |
500 mg | In stock | $ 2,970.00 |
Description | BRD6688 is a selective HDAC2 inhibitor that acts by enhancing the learning and memory processes |
Targets&IC50 | HDAC1:21 nM , HDAC3:11.48 μM, HDAC2:100 nM |
In vivo | Mouse in-vivo study showed that BRD6688 was able to increase the histone acetylation (H4K12 and H3K9) in hippocampal CA1 neurons of CK-p25 mice. Moreove, the increased histone acetylation in brain served as a surrogate pharmacodynamic marker of HDAC engagement and was consistent with previously observed brain pharmacokinetic properties. In addition, BRD6688 rescued the cognitive deficits in CK-p25 mice, a model of neurodegeneration, in a Pavlovian fear conditioning behavioral assay[1]. |
Molecular Weight | 282.34 |
Formula | C16H18N4O |
CAS No. | 1404562-17-9 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Ethanol: ≤2mg/ml
dimethyl formamide: 30mg/ml
DMSO: 30mg/ml
You can also refer to dose conversion for different animals. More
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
BRD6688 1404562-17-9 Chromatin/Epigenetic DNA Damage/DNA Repair HDAC Histone deacetylases inhibit BRD 6688 BRD-6688 Inhibitor inhibitor