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BU 224 hydrochloride is a selective imidazoline I(2) binding site ligand and has antinociceptive and antidepressant-like activities.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
2 mg | $29 | In Stock | |
5 mg | $48 | In Stock | |
10 mg | $73 | In Stock | |
25 mg | $158 | In Stock | |
50 mg | $253 | In Stock | |
100 mg | $367 | In Stock | |
200 mg | $515 | In Stock | |
1 mL x 10 mM (in DMSO) | $47 | In Stock |
Description | BU 224 hydrochloride is a selective imidazoline I(2) binding site ligand and has antinociceptive and antidepressant-like activities. |
In vivo | BU 224 hydrochloride (5 mg/kg; i.p.) attenuated spatial and perirhinal cortex-dependent recognition memory deficits in 5XFAD mice. Fear-conditioning testing revealed that BU 224 hydrochloride also improved both associative learning and hippocampal- and amygdala-dependent memory in transgenic but not in WT mice. In the brain, BU 224 hydrochloride reduced levels of the microglial marker Iba1 and pro-inflammatory cytokines IL-1β and TNF-α and increased the expression of astrocytic marker GFAP in 5XFAD mice[1]. |
Molecular Weight | 233.7 |
Formula | C12H12ClN3 |
Cas No. | 205437-64-5 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||
Solubility Information | DMSO: 3 mg/mL (12.84 mM), Sonication is recommended. | ||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||
DMSO
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