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BU 224 hydrochloride

Catalog No. T22051 CAS 205437-64-5

BU 224 hydrochloride is a selective imidazoline I(2) binding site ligand and has antinociceptive and antidepressant-like activities.

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BU 224 hydrochloride, CAS 205437-64-5

Pack Size	Availability	Price/USD
1 mg	In stock	$ 34.00
2 mg	In stock	$ 48.00
5 mg	In stock	$ 80.00
10 mg	In stock	$ 122.00
25 mg	In stock	$ 263.00
50 mg	In stock	$ 422.00
100 mg	In stock	$ 611.00
500 mg	In stock	$ 1,290.00
1 mL * 10 mM (in DMSO)	In stock	$ 79.00

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Purity: 99.2%

Biological Description

Chemical Properties

Storage & Solubility Information

Description

BU 224 hydrochloride is a selective imidazoline I(2) binding site ligand and has antinociceptive and antidepressant-like activities.

In vivo

BU 224 hydrochloride (5 mg/kg; i.p.) attenuated spatial and perirhinal cortex-dependent recognition memory deficits in 5XFAD mice. Fear-conditioning testing revealed that BU 224 hydrochloride also improved both associative learning and hippocampal- and amygdala-dependent memory in transgenic but not in WT mice. In the brain, BU 224 hydrochloride reduced levels of the microglial marker Iba1 and pro-inflammatory cytokines IL-1β and TNF-α and increased the expression of astrocytic marker GFAP in 5XFAD mice[1].

Molecular Weight	233.7
Formula	C12H12ClN3
CAS No.	205437-64-5

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 3 mg/mL (12.84 mM), Sonication is recommended.

References and Literature

1. Mirzaei N, et al. Imidazoline ligand BU224 reverses cognitive deficits, reduces microgliosis and enhances synaptic connectivity in a mouse model of Alzheimer's disease. Br J Pharmacol. 2021 Feb;178(3):654-671. 2. Min JW, et al. Gender difference in epileptogenic effects of 2-BFI and BU224 in mice. Eur J Pharmacol. 2013 Oct 15;718(1-3):81-6.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Neurodegenerative Disease Compound Library Bioactive Compounds Library Max Bioactive Compound Library Neuronal Signaling Compound Library Antidepressant Compound Library

Related Products

Related compounds with same targets

Rilmenidine hemifumarate Allantoin Harmane Idazoxan hydrochloride Agmatine sulfate Rilmenidine Phosphate CR4056 BU 226 hydrochloride

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

BU 224 hydrochloride 205437-64-5 Neuroscience Imidazoline Receptor BU 224 Tumor Necrosis Factor Receptor inhibit Inhibitor BU224 Imidazoline BU-224 TNF Receptor Alzheimer's disease TNFR Apoptosis BU224 Hydrochloride anti-apoptotic BU 224 Hydrochloride ACTH antidepressant BU-224 Hydrochloride neuroprotective 5-HT anti-inflammatory inhibitor

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