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Bavisant

Catalog No. TQ0046   CAS 929622-08-2
Synonyms: JNJ-31001074

Bavisant (JNJ-31001074) is a selective and orally active Human H3 receptor antagonist. Bavisant can be used in research on mechanisms of action, involving wakefulness and cognition and the treatment for ADHD.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.
Bavisant Chemical Structure
Bavisant, CAS 929622-08-2
Pack Size Availability Price/USD Quantity
1 mg In stock $ 60.00
5 mg In stock $ 147.00
10 mg In stock $ 228.00
25 mg In stock $ 389.00
50 mg In stock $ 573.00
100 mg In stock $ 816.00
500 mg In stock $ 1,630.00
1 mL * 10 mM (in DMSO) In stock $ 159.00
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Purity: 96.06%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Bavisant (JNJ-31001074) is a selective and orally active Human H3 receptor antagonist. Bavisant can be used in research on mechanisms of action, involving wakefulness and cognition and the treatment for ADHD.
In vivo Mean change from baseline in the total ADHD-RS-IV score at day 42 (primary efficacy endpoint) was -8.8 in the placebo group versus -9.3, -11.2, and -12.2 in the Bavisant 1 mg/day, 3 mg/day, and 10 mg/day groups, respectively; the change in the 10 mg/day group was not statistically superior to placebo, and hence statistical comparisons of the 1 mg/day and 3 mg/day groups with placebo based on a step-down closed testing procedure were not performed[1].
Synonyms JNJ-31001074
Molecular Weight 329.44
Formula C19H27N3O2
CAS No. 929622-08-2

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 13 mg/mL (39.46 mM)

TargetMolReferences and Literature

1. Weisler RH, Pandina GJ, Daly EJ. Randomized clinical study of a histamine H3 receptor antagonist for the treatment of adults with attention-deficit hyperactivity disorder. CNS Drugs. 2012 May 1;26(5):421-34. 2. Robert L, et al. Discovery and Characterization of 6-{4-[3-(R)-2-Methylpyrrolidin-1-yl)propoxy]phenyl}-2H-pyridazin-3-one (CEP-26401, Irdabisant): A Potent, Selective Histamine H3 Receptor Inverse Agonist. J. Med. Chem. 2011, 54, 4781-4792

Related compound libraries

This product is contained In the following compound libraries:
Anti-Cancer Clinical Compound Library Anti-Cancer Drug Library Anti-Neurodegenerative Disease Compound Library ReFRAME Related Library Neurotransmitter Receptor Compound Library Clinical Compound Library Inhibitor Library Bioactive Compound Library Bioactive Compounds Library Max Orally Active Compound Library

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Keywords

Bavisant 929622-08-2 GPCR/G Protein Immunology/Inflammation Neuroscience Histamine Receptor JNJ-31001074 Neurological disorders inhibit attention-deficit hyperactivity disorder ADHD cognition JNJ 31001074 wakefulness Inhibitor JNJ31001074 inhibitor

 

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