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Belvarafenib

Catalog No. T5634   CAS 1446113-23-0

Belvarafenib is a potent and pan RAF inhibitor with antineoplastic activity. The IC50 values of Belvarafenib are 56 nM, 7 nM and 5 nM for B-RAF, B-RAFv600E and C-RAF respectively.

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Belvarafenib Chemical Structure
Belvarafenib, CAS 1446113-23-0
Pack Size Availability Price/USD Quantity
1 mg In stock $ 40.00
2 mg In stock $ 56.00
5 mg In stock $ 97.00
10 mg In stock $ 172.00
25 mg In stock $ 288.00
50 mg In stock $ 428.00
100 mg In stock $ 637.00
1 mL * 10 mM (in DMSO) In stock $ 98.00
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Purity: 99.62%
Purity: 99.44%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Belvarafenib is a potent and pan RAF inhibitor with antineoplastic activity. The IC50 values of Belvarafenib are 56 nM, 7 nM and 5 nM for B-RAF, B-RAFv600E and C-RAF respectively.
Targets&IC50 B-RafV600E:7 nM, B-Raf:56 nM, C-Raf:5 nM
In vitro Belvarafenib ?is a potent and pan RAF inhibitor with antineoplastic activity.?The IC50 values of Belvarafenib are 56 nM, 7 nM and 5 nM for B-RAF, B-RAFv600E and C-RAF respectively.?It also shows high inhibitory activity for FMS, DDR1 and DDR2 kinases, with IC50s of 10 nM, 23 nM and 44 nM, respectively.
Molecular Weight 478.93
Formula C23H16ClFN6OS
CAS No. 1446113-23-0

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 25 mg/mL (52.2 mM)

TargetMolReferences and Literature

1. Son J B , Jung S H , Choi Ii W , et al. Thieno[3,2-d]pyrimidine derivatives having inhibitory activity on protein kinases[J]. 2015.

Related compound libraries

This product is contained In the following compound libraries:
Anti-Cancer Active Compound Library Anti-Cancer Clinical Compound Library Anti-Cancer Drug Library Anti-Pancreatic Cancer Compound Library Anti-Ovarian Cancer Compound Library Drug Repurposing Compound Library Bioactive Compounds Library Max Anti-Obesity Compound Library Glutamine Metabolism Compound Library Anti-Liver Cancer Compound Library

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Doramapimod Oncrasin-1 GW 5074 LY3009120 Sorafenib-d3 Sorafenib tosylate PLX-4720 Dabrafenib

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Keywords

Belvarafenib 1446113-23-0 MAPK Raf RG-6185 inhibit GDC-5573 HM 95573 GDC 5573 Inhibitor RG6185 RG 6185 HM95573 HM-95573 GDC5573 Raf kinases inhibitor

 

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