Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Belzutifan (MK-6482) is a potential treatment for clear cell renal cell carcinoma (ccRCC). Belzutifan is an orally active and selective HIF-2α inhibitor (IC50: 9 nM). Belzutifan , as a second-generation HIF-2α inhibitor, increases potency and improves pharmacokinetic profile.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 64.00 | |
5 mg | In stock | $ 155.00 | |
10 mg | In stock | $ 289.00 | |
25 mg | In stock | $ 488.00 | |
50 mg | In stock | $ 715.00 | |
100 mg | In stock | $ 987.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 169.00 |
Description | Belzutifan (MK-6482) is a potential treatment for clear cell renal cell carcinoma (ccRCC). Belzutifan is an orally active and selective HIF-2α inhibitor (IC50: 9 nM). Belzutifan , as a second-generation HIF-2α inhibitor, increases potency and improves pharmacokinetic profile. |
Targets&IC50 | HIF2α:9 nM |
In vitro | PT2977 effectively and dose-dependently decreased mRNA levels of human cyclin D1, a target gene regulated by HIF-2α. It leads to a rapid and dose-dependent reduction in EPO expression[1]. |
Synonyms | PT2977, MK-6482 |
Molecular Weight | 383.34 |
Formula | C17H12F3NO4S |
CAS No. | 1672668-24-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 50 mg/mL (130.43 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. More
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
Belzutifan 1672668-24-4 Angiogenesis Chromatin/Epigenetic HIF Inhibitor PT 2977 PT2977 HIFs MK-6482 MK 6482 HIF/HIF Prolyl-Hydroxylase inhibit HIF-PH Hypoxia-inducible factors PT-2977 MK6482 inhibitor