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Bradykinin

Catalog No. TP1277   CAS 58-82-2

Bradykinin is an inflammatory mediator. It is a peptide that causes blood vessels to dilate (enlarge) via the release of prostacyclin, nitric oxide, and Endothelium-Derived Hyperpolarizing Factor. Bradykinin is a physiologically and pharmacologically active peptide of the kinin group of proteins, consisting of nine amino acids.

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Bradykinin Chemical Structure
Bradykinin, CAS 58-82-2
Pack Size Availability Price/USD Quantity
5 mg In stock $ 58.00
10 mg In stock $ 85.00
25 mg In stock $ 148.00
50 mg In stock $ 256.00
100 mg In stock $ 454.00
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Purity: 100%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Bradykinin is an inflammatory mediator. It is a peptide that causes blood vessels to dilate (enlarge) via the release of prostacyclin, nitric oxide, and Endothelium-Derived Hyperpolarizing Factor. Bradykinin is a physiologically and pharmacologically active peptide of the kinin group of proteins, consisting of nine amino acids.
In vitro Bradykinin is a potent vasodilator peptide that exerts its vasodilatory action through stimulation of specific endothelial B2 receptors, thereby causing the release of prostacyclin, NO, and EDHF[1]. Bradykinin has been reported to be involved in the progression of many types of cancer. Bradykinin treatment stimulates ERK1/2 activation and IL-6 production thereby contributing to the invasion and migration of colorectal cancer cells. [2]. Exogenous bradykinin markedly inhibits TF expression in mRNA and protein level induced by LPS in a dose-dependent manner. The NO synthase antagonist L-NAME and PI3K inhibitor LY294002 dramatically abolish the inhibitory effects of bradykinin on tissue factor expression[3].
In vivo Application of 1 μM bradykinin to the ovary produces significant decreases in heart rate and mean arterial pressure. Application of 1 μM bradykinin to the ovary produces bradycardia and hypotension similar to the responses evoked when vagal innervation is intact in vagotomized animals[4]. Vascular bradykinin can improve pancreatic microcirculation and hemorheology in rats with severe acute pancreatitis. The pancreatic microcirculatory blood flow volume and velocity in the vascular bradykinin treatment group increases gradually after 48 h[5]. PI3K/Akt signaling pathway activation induced by bradykinin administration reduces the activity of GSK-3β and MAPK, and reduces NF-x03BA;B level in the nucleus, thereby inhibiting TF expression. Consistent with this, intraperitoneal injection of C57/BL6 mice with bradykinin also inhibits the thrombus formation induced by ligation of inferior vena cava[3].
Molecular Weight 1060.21
Formula C50H73N15O11
CAS No. 58-82-2

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 10mM

TargetMolReferences and Literature

1. Hornig B, et al. Role of bradykinin in mediating vascular effects of angiotensin-converting enzyme inhibitors inhumans. Circulation. 1997 Mar 4;95(5):1115-8.

TargetMolCitations

1. Zhang Y, Zhang X, Li Z, et al.Single particle tracking reveals SARS-CoV-2 regulating and utilizing dynamic filopodia for viral invasion.Science Bulletin.2023 2. Zhao S, Xu Q, Cui Y, et al.Salmonella effector SopB reorganizes cytoskeletal vimentin to maintain replication vacuoles for efficient infection.Nature Communications.2023, 14(1): 478. 3. Niezen L E, Sasaki T, Sadriaj D, et al.Detailed analysis of the effective and intra-particle diffusion coefficient of proteins at elevated pressure in columns packed with wide-pore core-shell particles.Journal of Chromatography A.2023: 464538.

Related compound libraries

This product is contained In the following compound libraries:
Anti-Cancer Clinical Compound Library Anti-Cancer Drug Library Peptide Compound Library Human Endogenous Metabolite Library Human Metabolite Library Anti-Cardiovascular Disease Compound Library Anti-Hypertension Compound Library Natural Product Library for HTS Natural Product Library Anti-Tumor Natural Product Library

Related Products

Related compounds with same targets
ELN-441958 R715 TFA(185052-09-9 free base) Bradykinin (acetate) Bombinakinin M acetate Lys-[Des-Arg9]Bradykinin,TFA Des-Arg9-[Leu8]-Bradykinin acetate SSR240612 Sar-[D-Phe8]-des-Arg9-Bradykinin acetate

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Keywords

Bradykinin 58-82-2 GPCR/G Protein Metabolism Endogenous Metabolite Bradykinin Receptor Serine endopeptidases inhibit Threonine proteases Inhibitor Serine proteases Ser/Thr Protease inhibitor

 

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