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Brinzolamide

Catalog No. T0142 CAS 138890-62-7

Synonyms: AL-4862

Brinzolamide (AL-4862) is a Carbonic Anhydrase Inhibitor. The mechanism of action of brinzolamide is as a Carbonic Anhydrase Inhibitor.

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Brinzolamide, CAS 138890-62-7

Pack Size	Availability	Price/USD
5 mg	In stock	$ 34.00
10 mg	In stock	$ 50.00
25 mg	In stock	$ 96.00
50 mg	In stock	$ 148.00
100 mg	In stock	$ 216.00
200 mg	In stock	$ 270.00
500 mg	In stock	$ 453.00
1 mL * 10 mM (in DMSO)	In stock	$ 42.00

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Purity: 100%

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Description	Brinzolamide (AL-4862) is a Carbonic Anhydrase Inhibitor. The mechanism of action of brinzolamide is as a Carbonic Anhydrase Inhibitor.
Targets&IC50	CA II:3.19 nM
In vitro	A 0.6 mg dose of Brinzolamide ophthalmic suspension reduces intraocular pressure in a dose-dependent manner in cynomolgus monkeys post-laser glaucoma surgery. Similarly, it lowers intraocular pressure in Dutch belted rabbits. Dosages of 1 mg/kg, 10 mg/kg, and 30 mg/kg of Brinzolamide prolong the sleep time induced by barbital in male CD-1 mice by 57%, 15%, and 35%, respectively. Less than 3% of Brinzolamide significantly increases both the percentage reduction and the mean decrease in intraocular pressure among patients with primary open-angle glaucoma or ocular hypertension compared to a placebo group. Additionally, a 2% Brinzolamide solution enhances optic nerve head blood flow and reduces intraocular pressure in resting Dutch belted rabbits.

Synonyms	AL-4862
Molecular Weight	383.51
Formula	C12H21N3O5S3
CAS No.	138890-62-7

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: < 1 mg/mL (insoluble or slightly soluble)

Ethanol: < 1 mg/mL (insoluble or slightly soluble)

DMSO: 71 mg/mL (185.1 mM)

References and Literature

1. DeSantis L, et al. Surv Ophthalmol, 2000, Suppl 2, S119-129. 2. Silver LH, et al. Surv Ophthalmol, 2000, 44 Suppl 2, S147-153. 3. Kaup M, et al. Br J Ophthalmol, 2004, 88(2), 257-262. 4. Barnes GE, et al. Surv Ophthalmol, 2000, 44 Suppl 2, S131-140. 5. Yamada M, et al. J Cereb Blood Flow Metab, 2000, 20(4), 709-717.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library EMA Approved Drug Library Drug Repurposing Compound Library FDA-Approved Drug Library Anti-Aging Compound Library Glycometabolism Compound Library Clinical Compound Library Bioactive Compounds Library Max Metabolism Compound Library Anti-Metabolism Disease Compound Library

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Keywords

Brinzolamide 138890-62-7 Metabolism Carbonic Anhydrase IOP glaucoma intraocular pressure Carbonate dehydratase inhibit Inhibitor atrial fluid AL4862 AL-4862 AL 4862 carbonic anhydrase II inhibitor

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