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Cell Cycle/Checkpoint Aurora Kinase CCT241736

CCT241736

Catalog No. T4428   CAS 1402709-93-6

CCT241736 is an orally bioavailable dual FLT3/Aurora kinase inhibitor that also inhibits clinically relevant FLT3-resistant mutants including FLT3-ITD and FLT3, CCT241736, an advanced analog of CCT137690, is a preclinical development candidate for the treatment of human malignancies, and in particular AML in adults and children.

CCT241736, CAS 1402709-93-6
Pack Size Availability Price/USD Quantity
5 mg In stock 68.00
10 mg In stock 110.00
25 mg In stock 218.00
50 mg In stock 430.00
100 mg In stock 671.00
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Biological Description
Chemical Properties
Storage & Solubility Information
Description CCT241736 is an orally bioavailable dual FLT3/Aurora kinase inhibitor that also inhibits clinically relevant FLT3-resistant mutants including FLT3-ITD and FLT3, CCT241736, an advanced analog of CCT137690, is a preclinical development candidate for the treatment of human malignancies, and in particular AML in adults and children.
Targets&IC50 FLT3,   Aurora Kinase,  
In vivo UNC2025 was capable of inhibiting Mer phosphorylation in vivo, following oral dosing as demonstrated by pharmaco-dynamic (PD) studies examining phospho-Mer in leukemic blasts from mouse bone marrow.
Molecular Weight 456.37
Formula C22H23Cl2N7
CAS No. 1402709-93-6

Storage

-20℃ 3 years powder

-80℃ 2 years in solvent

Solubility Information

H2O: < 0.1 mg/mL (insoluble)

DMSO: 75 mg/mL (164.34 mM), Need ultrasonic

( < 1 mg/ml refers to the product slightly soluble or insoluble )

Citations

References and Literature
1. Bavetsias V,etal. Optimization of imidazo[4,5-b]pyridine-based kinase inhibitors: identification of a dual FLT3/Aurora kinase inhibitor as an orally bioavailable preclinical development candidate for the treatment of acute myeloid leukemia.J Med Chem. 2012 Oct 25;55(20):8721-34. 2. Bavetsias V,etal.Aurora Kinase Inhibitors: Current Status and Outlook.Front Oncol. 2015 Dec 21;5:278.

Related compound libraries

This product is contained In the following compound libraries:
Bioactive Compound Library Anti-cancer Compound Library Epigenetics Compound Library

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Related compounds with same targets
NVP-AEW541 SP-146 Sorafenib Sorafenib tosylate Aurora Kinase Inhibitor III SNS-314 Mesylate 3-Hydroxy Midostaurin Aurora inhibitor 1

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