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CGP 20712 A

Catalog No. T10778 CAS 105737-62-0

Synonyms: CGP 20712 mesylate

CGP 20712 A (CGP 20712 mesylate) is a highly selective antagonist of β1-adrenoceptor (IC50: 0.7 nM). It shows ~10,000-fold selectivity over β2-adrenoceptors.

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CGP 20712 A, CAS 105737-62-0

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	CGP 20712 A (CGP 20712 mesylate) is a highly selective antagonist of β1-adrenoceptor (IC50: 0.7 nM). It shows ~10,000-fold selectivity over β2-adrenoceptors.
Targets&IC50	β1-adrenoceptor:0.7 nM
In vitro	In myocytes, the activation of adenylate cyclase causes by β2-adrenoceptors is not detected in the presence of 10 nM, 100 nM, or 1000 nM CGP 20712 A [2].
In vivo	In 8-day-old rats, pretreatment with 5 mg/kg CGP 20712 A does not change the plasma ACTH response to insulin injection [3].

Synonyms	CGP 20712 mesylate
Molecular Weight	590.57
Formula	C24H29F3N4O8S
CAS No.	105737-62-0

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 100 mg/mL (169.33 mM), Need ultrasonic

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Dooley DJ, et al. CGP 20712 A: a useful tool for quantitating beta 1- and beta 2-adrenoceptors. Eur J Pharmacol. 1986 Oct 14;130(1-2):137-9. 2. Kitagawa Y, et al. Determination of beta-adrenoceptor subtype on rat isolated ventricular myocytes by use of highly selective beta-antagonists. Br J Pharmacol. 1995 Sep;116(1):1635-43. 3. Grino M, et al. Ontogeny of insulin-induced hypoglycemia stimulation of adrenocorticotropin secretion in the rat: role of catecholamines. Endocrinology. 1992 Dec;131(6):2763-8.

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed n the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

CGP 20712 A 105737-62-0 GPCR/G Protein Neuroscience Adrenergic Receptor CGP 20712 mesylate Inhibitor inhibitor inhibit

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