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CGP 20712 A
CGP 20712 A (CGP 20712 mesylate) is a selective and potent β1-adrenergic receptor antagonist (IC50: 0.7 nM) with antihypertensive activity, capable of reversing RKT-induced gastric relaxation.
Catalog No. T10778Cas No. 105737-62-0
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Purity:99.37%
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CGP 20712 A
Catalog No. T10778Cas No. 105737-62-0
CGP 20712 A (CGP 20712 mesylate) is a selective and potent β1-adrenergic receptor antagonist (IC50: 0.7 nM) with antihypertensive activity, capable of reversing RKT-induced gastric relaxation.
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose. | Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $148 | In Stock | |
| 5 mg | $372 | In Stock | |
| 10 mg | $548 | In Stock | |
| 25 mg | $869 | In Stock | |
| 50 mg | $1,170 | In Stock | |
| 100 mg | $1,570 | In Stock |
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | CGP 20712 A (CGP 20712 mesylate) is a selective and potent β1-adrenergic receptor antagonist (IC50: 0.7 nM) with antihypertensive activity, capable of reversing RKT-induced gastric relaxation. |
| Targets&IC50 | β1-adrenoceptor:0.7 nM, β1-adrenoceptor:0.7 nM |
| In vitro | In myocyte, saturation experiments conducted in the presence of 300nM CGP 20712A failed to detect specific binding of [125I]-ICYP and [3H]-CGP 12177[2]. |
| In vivo | Pre-treatment with 5mg/kg CGP 20712A (selective β1-adrenoceptor antagonist) in 8-day-old rats did not alter the plasma ACTH response to insulin injection[3]. |
| Alias | CGP 20712 mesylate |
| Molecular Weight | 590.57 |
| Formula | C24H29F3N4O8S |
| Cas No. | 105737-62-0 |
| Storage | keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 80 mg/mL (135.46 mM), Sonification is recommended. | |||||||||||||||||||||||||||||||||||
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
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DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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