Powder: -20°C for 3 years | In solvent: -80°C for 1 year
CHDI-390576 is a CNS penetrant class IIa HDAC inhibitor (IC50s: 54 nM, 60 nM, 31 nM, 50 nM for class IIa HDAC4, HDAC5, HDAC7, HDAC9). It shows <500-fold selectivity over class I HDACs (1, 2, 3) and ~150-fold selectivity over HDAC8 and the class IIb HDAC6 isoform.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
2 mg | 5 days | $ 80.00 |
Description | CHDI-390576 is a CNS penetrant class IIa HDAC inhibitor (IC50s: 54 nM, 60 nM, 31 nM, 50 nM for class IIa HDAC4, HDAC5, HDAC7, HDAC9). It shows >500-fold selectivity over class I HDACs (1, 2, 3) and ~150-fold selectivity over HDAC8 and the class IIb HDAC6 isoform. |
Targets&IC50 | HDAC8:9.1 μM, HDAC6 (human):6.2 μM, HDAC1:39.7 μM, HDAC9 (human):50 nM, HDAC3:25.8 μM, HDAC5:60 nM, HDAC7:31 nM, HDAC4:54 nM |
In vitro | CHDI-390576 inhibits class I HDACs (1, 3, 8) and class IIb HDAC6 isoforms (IC50s: 39.7μM, 25.8 μM, 9.1 μM, 6.2 μM). To the catalytic domain of immobilized HDAC4, the Kd of CHDI-390576 is 80 nM. |
Molecular Weight | 391.32 |
Formula | C19H13F4N3O2 |
CAS No. | 1629729-98-1 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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CHDI-390576 1629729-98-1 Chromatin/Epigenetic DNA Damage/DNA Repair HDAC CHDI390576 CHDI 390576 inhibitor inhibit