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CM-272

Catalog No. T7194   CAS 1846570-31-7
Synonyms: DNMT1, anti-tumour, DNMTs, immunogenic, DNA MTases, CM272, DNMT3A, CM 272, G9a, H3K9me2, Inhibitor, epigenetics, Histone Methyltransferase, GLP, Apoptosis, inhibit, substrate-competitive, CM-272, DNMT3B, DNA Methyltransferase

CM-272 is a dual G9a/DNA methyltransferases (DNMTs) inhibitor.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.
CM-272, CAS 1846570-31-7
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Purity: 98%
Biological Description
Chemical Properties
Storage & Solubility Information
Description CM-272 is a dual G9a/DNA methyltransferases (DNMTs) inhibitor.
Targets&IC50 G9a:8 nM, DNMT3B:1200 nM (IC50), DNMT3a:85 nM, GLP:2 nM, DNMT1:382 nM
In vitro CM-272, inhibits cell proliferation and promotes apoptosis, inducing interferon-stimulated genes and immunogenic cell death. CM-272 significantly prolongs survival of AML, ALL and DLBCL xenogeneic models.
In vivo CM-272 (2.5 mg/kg; intravenous injection; daily; for 28 days; female Rag2?/?γc?/? mice) treatment significantly prolongs survival of CEMO-1 cells xenogeneic models.Induced a statistically significant increase in overall survival (OS) in mice.
Cell Research Cell Line:CEMO-1, MV4-11 and OCI-Ly10 cell lines. Concentration:125 nM, 250 nM, 500 nM (CEMO-1 cells); 135 nM, 270 nM, 540 nM (MV4-11 cells); 100 nM, 400 nM, 1000 nM (OCI-Ly10 cells). Incubation Time:12 hours, 24 hours, 48 hours and 72?hours
Animal Research CM-272 (2.5 mg/kg; intravenous injection; daily; for 28 days; female Rag2?/?γc?/? mice) treatment significantly prolongs survival of CEMO-1 cells xenogeneic models. Animal Model:Female BALB/Ca-Rag2?/?γc?/? mice (6–8-week-old) with CEMO-1 cells. Dosage:2.5 mg/kg. Administration:Intravenous injection; daily; for 28 days
Synonyms DNMT1, anti-tumour, DNMTs, immunogenic, DNA MTases, CM272, DNMT3A, CM 272, G9a, H3K9me2, Inhibitor, epigenetics, Histone Methyltransferase, GLP, Apoptosis, inhibit, substrate-competitive, CM-272, DNMT3B, DNA Methyltransferase
Molecular Weight 478.637
Formula C28H38N4O3
CAS No. 1846570-31-7

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 96 mg/mL (200.57 mM)

Ethanol: 96 mg/mL (200.57 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

Citations

References and Literature
1. San José-Enériz, Edurne, Agirre X , Rabal O , et al. Discovery of first-in-class reversible dual small molecule inhibitors against G9a and DNMTs in hematological malignancies[J]. Nature Communications, 2017, 8:15424.

Related compound libraries

This product is contained In the following compound libraries:
Anti-Cancer Compound Library Inhibitor Library Immunology/Inflammation Compound Library Stem Cell Differentiation Compound Library Chromatin Modification Compound Library Apoptosis Compound Library Epigenetics Compound Library Bioactive Compound Library

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