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CM-272

Catalog No. T7194 CAS 1846570-31-7

Synonyms: DNMT1, anti-tumour, DNMTs, immunogenic, DNA MTases, CM272, DNMT3A, CM 272, G9a, H3K9me2, Inhibitor, epigenetics, Histone Methyltransferase, GLP, Apoptosis, inhibit, substrate-competitive, CM-272, DNMT3B, DNA Methyltransferase

CM-272 is a dual G9a/DNA methyltransferases (DNMTs) inhibitor.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

CM-272, CAS 1846570-31-7

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	CM-272 is a dual G9a/DNA methyltransferases (DNMTs) inhibitor.
Targets&IC50	G9a:8 nM, DNMT3B:1200 nM (IC50), DNMT3a:85 nM, GLP:2 nM, DNMT1:382 nM
In vitro	CM-272, inhibits cell proliferation and promotes apoptosis, inducing interferon-stimulated genes and immunogenic cell death. CM-272 significantly prolongs survival of AML, ALL and DLBCL xenogeneic models.
In vivo	CM-272 (2.5 mg/kg; intravenous injection; daily; for 28 days; female Rag2?/?γc?/? mice) treatment significantly prolongs survival of CEMO-1 cells xenogeneic models.Induced a statistically significant increase in overall survival (OS) in mice.
Cell Research	Cell Line:CEMO-1, MV4-11 and OCI-Ly10 cell lines. Concentration:125 nM, 250 nM, 500 nM (CEMO-1 cells); 135 nM, 270 nM, 540 nM (MV4-11 cells); 100 nM, 400 nM, 1000 nM (OCI-Ly10 cells). Incubation Time:12 hours, 24 hours, 48 hours and 72?hours
Animal Research	CM-272 (2.5 mg/kg; intravenous injection; daily; for 28 days; female Rag2?/?γc?/? mice) treatment significantly prolongs survival of CEMO-1 cells xenogeneic models. Animal Model:Female BALB/Ca-Rag2?/?γc?/? mice (6–8-week-old) with CEMO-1 cells. Dosage:2.5 mg/kg. Administration:Intravenous injection; daily; for 28 days

Synonyms	DNMT1, anti-tumour, DNMTs, immunogenic, DNA MTases, CM272, DNMT3A, CM 272, G9a, H3K9me2, Inhibitor, epigenetics, Histone Methyltransferase, GLP, Apoptosis, inhibit, substrate-competitive, CM-272, DNMT3B, DNA Methyltransferase
Molecular Weight	478.637
Formula	C28H38N4O3
CAS No.	1846570-31-7

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 96 mg/mL (200.57 mM)

Ethanol: 96 mg/mL (200.57 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

Citations

References and Literature

1. San José-Enériz, Edurne, Agirre X , Rabal O , et al. Discovery of first-in-class reversible dual small molecule inhibitors against G9a and DNMTs in hematological malignancies[J]. Nature Communications, 2017, 8:15424.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Compound Library Inhibitor Library Immunology/Inflammation Compound Library Stem Cell Differentiation Compound Library Chromatin Modification Compound Library Apoptosis Compound Library Epigenetics Compound Library Bioactive Compound Library

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.