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Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $50 | In Stock | |
5 mg | $112 | In Stock | |
10 mg | $198 | In Stock | |
25 mg | $329 | In Stock | |
50 mg | $492 | In Stock | |
100 mg | $717 | In Stock |
Description | CZC-25146 is a selective LRRK2 inhibitor with IC50 of 4.76 nM/6.87 nM for wild type LRRK2 and G2019S LRRK2, respectively. |
In vitro | CZC-25146 inhibited only five kinases(PLK4, GAK, TNK1, CAMKK2, and PIP4K2C) with high potency. CZC-25146 neither caused cytotoxicity in human cortical neurons at concentrations below 5 μM over a seven-day treatment in culture nor did it block neuronal development in vitro. |
In vivo | CZC-25146 possesses favorable pharmacokinetic properties, such as a volume of distribution of 5.4 L/kg and clearance of 2.3 L/hr/kg that render it suitable for in-vivo studies. |
Molecular Weight | 525 |
Formula | C22H26ClFN6O4S |
Cas No. | 1330003-04-7 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | |||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 55 mg/mL (104.76 mM) ![]() | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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