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Carbimazole

Catalog No. T0952 CAS 22232-54-8

Synonyms: Athyromazole, Carbimazol, Neomercazole

Carbimazole (Athyromazole) is an Imidazolium thyroid antagonist, which is rapidly transformed into MMI in vivo and can be converted into methidazole in vitro, and can be used in the study of Graves' disease.

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Carbimazole, CAS 22232-54-8

Pack Size	Availability	Price/USD	Quantity
500 mg	In stock	$ 46.00
1 mL * 10 mM (in DMSO)	In stock	$ 48.00

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Purity: 99.22%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Carbimazole (Athyromazole) is an Imidazolium thyroid antagonist, which is rapidly transformed into MMI in vivo and can be converted into methidazole in vitro, and can be used in the study of Graves' disease.
In vivo	Once absorbed by the human body, Carbimazole is metabolized into Methimazole, which exerts anti-thyroid activity. It specifically targets conditions such as hyperthyroidism (excessive production of thyroid hormones) and thyrotoxicosis (thyroid inflammation).
Kinase Assay	In vitro kinase assays: with purified proteins, recombinant S6 protein and recombinant active P70S6K are incubated in 1x kinase buffer with various amount of HCQ or RAD001 in the presence (25 μM) or absence of ATP for 30 minutes at 30°C. Total and phosphorylated S6 at ser235/236 and ser240/244 are detected by western analysis using phosphospecific antibodies. Note that recombinant GST-tagged S6 (53 kd) is distinguished from endogenous S6 (32 kd) on the western blot.

Synonyms	Athyromazole, Carbimazol, Neomercazole
Molecular Weight	186.23
Formula	C7H10N2O2S
CAS No.	22232-54-8

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

Ethanol: 12 mg/mL (64.4 mM)

DMSO: 36 mg/mL (193.3 mM)

H2O: < 1 mg/mL (insoluble or slightly soluble)

References and Literature

1. Taurog A, et al. Endocrinology, 1976, 98(4), 1031-1046. 2. Magnusson RP, et al. J Biol Chem, 1984, 259(1), 197-205.

Related compound libraries

This product is contained In the following compound libraries：

Drug Repurposing Compound Library ReFRAME Related Library Approved Drug Library FDA-Approved & Pharmacopeia Drug Library Drug-Fragment Library Endocrinology-Hormone Compound Library Orally Active Compound Library NO PAINS Compound Library Immunology/Inflammation Compound Library Anti-Metabolism Disease Compound Library

Related Products

Related compounds with same targets

Glutaurine aceate Methimazole Resmetirom AH-3960 DPC AJ1951 acetate PCO371 Taltirelin acetate Propylthiouracil

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Keywords

Carbimazole 22232-54-8 Endocrinology/Hormones Thyroid hormone receptor(THR) antithyroid agent MMI inhibit Graves' disease Inhibitor Athyromazole methimazole Carbimazol Neomercazole inhibitor

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