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Casein Kinase II Inhibitor IV

Casein Kinase II Inhibitor IV
Casein Kinase II Inhibitor IV is an inducer of epidermal keratinocyte differentiation.
Catalog No. T10687Cas No. 863598-09-8
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Purity:99.32%
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Casein Kinase II Inhibitor IV

Catalog No. T10687Cas No. 863598-09-8
Casein Kinase II Inhibitor IV is an inducer of epidermal keratinocyte differentiation.
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
Pack SizePriceAvailabilityQuantity
1 mg$79In Stock
5 mg$173In Stock
10 mg$273In Stock
25 mg$451In Stock
50 mg$636In Stock
100 mg$858In Stock
500 mg$1,710In Stock
1 mL x 10 mM (in DMSO)$190In Stock
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Product Introduction

Bioactivity
Description
Casein Kinase II Inhibitor IV is an inducer of epidermal keratinocyte differentiation.
In vitro
Treatment with Casein Kinase II Inhibitor IV on human epidermal keratinocytes (NHEKs) enhances early differentiation markers, keratins 1 and 10, at 48 hours, while increasing levels of IVL and TGM at 72 hours, sustained through 96 hours. This inhibitor also prompts the expression of loricrin, a terminal differentiation marker, at subsequent time points. Correspondingly, mRNA expression analysis confirms upregulation of early differentiation marker genes, specifically keratin 1 and keratin 10 by 5.4-fold at 12 and 24 hours. Late-differentiation marker genes, including IVL (1.8-fold), TGM 1 (4.8-fold), loricrin (3.3-fold), and filaggrin (5.6-fold), exhibit increased expression at 36 and 48 hours in NHEKs treated with Casein Kinase II Inhibitor IV.
Chemical Properties
Molecular Weight429.47
FormulaC24H23N5O3
Cas No.863598-09-8
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 70 mg/mL (162.99 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.3285 mL11.6423 mL23.2845 mL116.4226 mL
5 mM0.4657 mL2.3285 mL4.6569 mL23.2845 mL
10 mM0.2328 mL1.1642 mL2.3285 mL11.6423 mL
20 mM0.1164 mL0.5821 mL1.1642 mL5.8211 mL
50 mM0.0466 mL0.2328 mL0.4657 mL2.3285 mL
100 mM0.0233 mL0.1164 mL0.2328 mL1.1642 mL

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