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Casein Kinase II Inhibitor IV
Catalog No. T10687Cas No. 863598-09-8
Casein Kinase II Inhibitor IV is an inducer of epidermal keratinocyte differentiation.
Casein Kinase II Inhibitor IV
Catalog No. T10687Cas No. 863598-09-8
Casein Kinase II Inhibitor IV is an inducer of epidermal keratinocyte differentiation.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $79 | In Stock | |
| 5 mg | $173 | In Stock | |
| 10 mg | $273 | In Stock | |
| 25 mg | $451 | In Stock | |
| 50 mg | $636 | In Stock | |
| 100 mg | $858 | In Stock | |
| 500 mg | $1,710 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $190 | In Stock |
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Purity:99.32%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | Casein Kinase II Inhibitor IV is an inducer of epidermal keratinocyte differentiation. |
| In vitro | Treatment with Casein Kinase II Inhibitor IV on human epidermal keratinocytes (NHEKs) enhances early differentiation markers, keratins 1 and 10, at 48 hours, while increasing levels of IVL and TGM at 72 hours, sustained through 96 hours. This inhibitor also prompts the expression of loricrin, a terminal differentiation marker, at subsequent time points. Correspondingly, mRNA expression analysis confirms upregulation of early differentiation marker genes, specifically keratin 1 and keratin 10 by 5.4-fold at 12 and 24 hours. Late-differentiation marker genes, including IVL (1.8-fold), TGM 1 (4.8-fold), loricrin (3.3-fold), and filaggrin (5.6-fold), exhibit increased expression at 36 and 48 hours in NHEKs treated with Casein Kinase II Inhibitor IV. |
| Molecular Weight | 429.47 |
| Formula | C24H23N5O3 |
| Cas No. | 863598-09-8 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 70 mg/mL (162.99 mM), Sonication is recommended.  | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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