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Ciclesonide

Catalog No. T2526   CAS 126544-47-6
Synonyms: Zetonna, RPR251526, Omnaris, Alvesco

Ciclesonide (Alvesco)(RPR251526) is a glucocorticoid used for the treatment of obstructive airway diseases.

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Ciclesonide Chemical Structure
Ciclesonide, CAS 126544-47-6
Pack Size Availability Price/USD Quantity
5 mg In stock $ 34.00
10 mg In stock $ 46.00
25 mg In stock $ 79.00
50 mg In stock $ 132.00
100 mg In stock $ 213.00
500 mg In stock $ 533.00
1 mL * 10 mM (in DMSO) In stock $ 50.00
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Purity: 100%
Purity: 99.89%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Ciclesonide (Alvesco)(RPR251526) is a glucocorticoid used for the treatment of obstructive airway diseases.
In vitro Ciclesonide is effectively taken up into human alveolar type II epithelial (A549) cells and metabolized to its pharmacologically active metabolite des-CIC and fatty acid conjugates of desCIC[2].
Cell Research Metabolism of ciclesonide: After initial cultivation, A549 cells are washed five times with 10 ml/dish sterile PBS. An ethanolic stock solution of ciclesonide is diluted 1000-fold with assay medium to generate the initial ciclesonide concentration. The cells are incubated for 1 h in DMEM/0.1% (w/v) BSA (5 ml/dish) containing 0.02 μM ciclesonide as described above in a CO2 incubator. At the end of the incubation period, dishes are washed five times with PBS and incubated for 3, 6, or 24 h at the same conditions in 5 ml/dish fresh medium (DMEM/0.1% (w/v) BSA). At each indicated time point, the medium is removed by aspiration, 5 mM EDTA-4Na/PBS added and dishes are incubated for further 5 min. The cells are detached from the dishes and harvested. Each dish is washed five times with icechilled PBS. (Only for Reference)
Synonyms Zetonna, RPR251526, Omnaris, Alvesco
Molecular Weight 540.69
Formula C32H44O7
CAS No. 126544-47-6

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

Ethanol: 54.1 mg/mL (100 mM)

DMSO: 54.1 mg/mL (100 mM)

TargetMolReferences and Literature

1. Guo Z, et al. Am J Ther. 2006, 13(6):490-501. 2. Nonaka T, et al. BMC Pharmacol. 2007, 7:12.

Related compound libraries

This product is contained In the following compound libraries:
Anti-Cancer Approved Drug Library Anti-Cancer Drug Library Anti-Cancer Clinical Compound Library Pediatric Drug Library Approved Drug Library Anti-COVID-19 Compound Library Immunology/Inflammation Compound Library NO PAINS Compound Library Orally Active Compound Library Endocrinology-Hormone Compound Library

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Keywords

Ciclesonide 126544-47-6 Endocrinology/Hormones Glucocorticoid Receptor Inhibitor Zetonna RPR 251526 RPR251526 Omnaris RPR-251526 inhibit Alvesco inhibitor

 

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