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Cyclosporine

Catalog No. T6459 CAS 79217-60-0

Cyclosporine is a calcineurin phosphatase pathway inhibitor, used as an immunosuppressant drug to prevent rejection in organ transplantation.

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Cyclosporine, CAS 79217-60-0

Pack Size	Availability	Price/USD
10 mg	In stock	$ 30.00
25 mg	In stock	$ 47.00
50 mg	In stock	$ 89.00
100 mg	In stock	$ 128.00
500 mg	In stock	$ 326.00
1 mL * 10 mM (in DMSO)	In stock	$ 44.00

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Purity: 99.68%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Cyclosporine is a calcineurin phosphatase pathway inhibitor, used as an immunosuppressant drug to prevent rejection in organ transplantation.
In vitro	Cyclosporine induces phenotypic changes, including invasiveness of non-transformed cells, by a cell-autonomous mechanism. Cyclosporine treatment of adenocarcinoma cells results in striking morphological alterations, including membrane ruffling and numerous pseudopodial protrusions, increased cell motility, and anchorage-independent (invasive) growth. [1] Cyclosporine (cyclosporin A, CsA) has potent immunosuppressive properties, reflecting its ability to block the transcription of cytokine genes in activated T cells. Cyclosporine through formation of a complex with cyclophilin inhibits the phosphatase activity of calcineurin, which regulates nuclear translocation and subsequent activation of NFAT transcription factors. Cyclosporine also blocks the activation of JNK and p38 signaling pathways triggered by antigen recognition, making CsA a highly specific inhibitor of T cell activation. [2] Cyclosporine-mediated inhibition of the biliary excretion of MPAG by the Mrp2 transporter is the mechanism responsible for the interaction between Cyclosporine and mycophenolate mofetil (MMF). [3] Cyclosporine inhibits biochemical and morphological differentiation of skeletal muscle cells while having a minimal effect on proliferation. [4]
In vivo	Cyclosporine enhances tumour growth in immunodeficient SCID-beige mice. [1] Cyclosporine inhibits muscle regeneration after induced trauma in mice. [4] Cyclosporine peaks at 1 hour in blood, spleen, and kidney, with higher concentrations in spleen and kidney than in blood. [5]

Molecular Weight	1202.61
Formula	C62H111N11O12
CAS No.	79217-60-0

Storage

keep away from moisture

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: < 1 mg/mL (insoluble or slightly soluble)

Ethanol: 93 mg/mL (77.3 mM)

DMSO: 93 mg/mL (77.3 mM)

References and Literature

1. Hojo M, et al. Nature, 1999, 397(6719), 530-534. 2. Matsuda S, et al. Immunopharmacology, 2000, 47(2-3), 119-125. 3. Hesselink DA, et al. Am J Transplant, 2005, 5(5), 1987-1994. 4. Abbott KL, et al. Mol Biol Cell, 1998, 9(10), 2905-2916. 5. Lang E, et al. Pain, 1996, 68(1), 151-155.

Related compound libraries

This product is contained In the following compound libraries：

Peptide Compound Library Drug Repurposing Compound Library Pediatric Drug Library Approved Drug Library Anti-Metabolism Disease Compound Library Orally Active Compound Library Immunology/Inflammation Compound Library Macrocyclic Compound Library Clinical Compound Library Bioactive Compound Library

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Keywords

Cyclosporine 79217-60-0 Metabolism Phosphatase inhibitor inhibit

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