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DJ-V-159

Catalog No. T5100Cas No. 2253744-53-3
Alias DJ-V159

DJ-V-159 is a GPRC6A agonist, targeting the G protein-coupled receptor family C group 6 member A (GPRC6A).

DJ-V-159

DJ-V-159

Purity: 99.96%
Catalog No. T5100Alias DJ-V159Cas No. 2253744-53-3
DJ-V-159 is a GPRC6A agonist, targeting the G protein-coupled receptor family C group 6 member A (GPRC6A).
Pack SizePriceAvailabilityQuantity
2 mg$30In Stock
5 mg$48In Stock
10 mg$79In Stock
25 mg$162In Stock
50 mg$283In Stock
100 mg$455In Stock
500 mg$987In Stock
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Purity:99.96%
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Product Introduction

Bioactivity
Description
DJ-V-159 is a GPRC6A agonist, targeting the G protein-coupled receptor family C group 6 member A (GPRC6A).
In vitro
DJ-V159 activates ERK in HEK-293 cells transfected with GPRC6A but not in non-transfected HEK-293 cells, with potency similar to L-Arg. Additionally, DJ-V159 dose-dependently stimulates cAMP production in GPRC6A-expressing HEK-293 cells at 0.2 nM concentrations in the media. DJ-V159 also stimulates insulin secretion in mouse beta-cell MIN-6 cells, with an insulin stimulation index (SI) similar to Ocn, a known ligand of GPRC6A [1].
In vivo
DJ-V-159 (10 mg/kg, i.p.) reduces blood glucose levels in wild-type mice at 60 and 90 minutes, whereas the vehicle (95% PEG + 5% DMSO) has no effect on blood glucose. DJ-V-159 (10 mg/kg, i.p.) reduces blood glucose levels in wild-type mice by 43.6% and 41.9% at 60 and 90 minutes, respectively. The mice tolerated this short-term exposure to DJ-V-159 without any overt side-effects. DJ-V-159, however, is almost in or on the boundary of the Lipinski's Rule of Five [1].
AliasDJ-V159
Chemical Properties
Molecular Weight502.37
FormulaC24H12F6N4O2
Cas No.2253744-53-3
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 5.02 mg/mL (10 mM)
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM1.9906 mL9.9528 mL19.9056 mL99.5282 mL
5 mM0.3981 mL1.9906 mL3.9811 mL19.9056 mL
10 mM0.1991 mL0.9953 mL1.9906 mL9.9528 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
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