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DJ-V-159 is a GPRC6A agonist, targeting the G protein-coupled receptor family C group 6 member A (GPRC6A).
Pack Size | Price | Availability | Quantity |
---|---|---|---|
2 mg | $30 | In Stock | |
5 mg | $48 | In Stock | |
10 mg | $79 | In Stock | |
25 mg | $162 | In Stock | |
50 mg | $283 | In Stock | |
100 mg | $455 | In Stock | |
500 mg | $987 | In Stock |
Description | DJ-V-159 is a GPRC6A agonist, targeting the G protein-coupled receptor family C group 6 member A (GPRC6A). |
In vitro | DJ-V159 activates ERK in HEK-293 cells transfected with GPRC6A but not in non-transfected HEK-293 cells, with potency similar to L-Arg. Additionally, DJ-V159 dose-dependently stimulates cAMP production in GPRC6A-expressing HEK-293 cells at 0.2 nM concentrations in the media. DJ-V159 also stimulates insulin secretion in mouse beta-cell MIN-6 cells, with an insulin stimulation index (SI) similar to Ocn, a known ligand of GPRC6A [1]. |
In vivo | DJ-V-159 (10 mg/kg, i.p.) reduces blood glucose levels in wild-type mice at 60 and 90 minutes, whereas the vehicle (95% PEG + 5% DMSO) has no effect on blood glucose. DJ-V-159 (10 mg/kg, i.p.) reduces blood glucose levels in wild-type mice by 43.6% and 41.9% at 60 and 90 minutes, respectively. The mice tolerated this short-term exposure to DJ-V-159 without any overt side-effects. DJ-V-159, however, is almost in or on the boundary of the Lipinski's Rule of Five [1]. |
Alias | DJ-V159 |
Molecular Weight | 502.37 |
Formula | C24H12F6N4O2 |
Cas No. | 2253744-53-3 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||
Solubility Information | DMSO: 5.02 mg/mL (10 mM) | ||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||
DMSO
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