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DMCM hydrochloride

Catalog No. T11061 CAS 1215833-62-7

DMCM hydrochloride is a non-selective fully inverse agonist of benzodiazepine. DMCM showed significant differences in human recombinant GABAA αxβ3γ2 receptor subtypes. For α1, α2, α3, and α5 receptors, their Kis were 10 nM, 13 nM, 7.5 nM, 2.2 nM, respectively.

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DMCM hydrochloride, CAS 1215833-62-7

Pack Size	Availability	Price/USD
1 mg	In stock	$ 41.00
5 mg	In stock	$ 97.00
10 mg	In stock	$ 147.00
25 mg	In stock	$ 327.00
50 mg	In stock	$ 597.00
100 mg	In stock	$ 852.00
1 mL * 10 mM (in DMSO)	In stock	$ 98.00

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Purity: 98.95%

Biological Description

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Storage & Solubility Information

Description	DMCM hydrochloride is a non-selective fully inverse agonist of benzodiazepine. DMCM showed significant differences in human recombinant GABAA αxβ3γ2 receptor subtypes. For α1, α2, α3, and α5 receptors, their Kis were 10 nM, 13 nM, 7.5 nM, 2.2 nM, respectively.
Targets&IC50	GABAA α3 receptor:7.5 nM (ki), GABAA α1 receptor:ki:10 nM , GABAA α5 receptor:2.2 nM (ki), GABAA α2 receptor:13 nM (ki)
In vivo	DMCM has potent convulsant, proconvulsant and anxiogenic properties in vivo. DMCM (20-60 mg/kg; i.p.) produces modest anxiolytic-like effects in γ2I77 mice[2].

Molecular Weight	350.8
Formula	C17H19ClN2O4
CAS No.	1215833-62-7

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: 22.5 mg/mL (64.1 mM), Sonication is recommended.

DMSO: 9 mg/mL (25.7 mM), Sonication is recommended.

References and Literature

1. Chambers MS, et al. An orally bioavailable, functionally selective inverse agonist at the benzodiazepine site of GABAA alpha5 receptors with cognition enhancing properties. J Med Chem. 2004 Nov 18;47(24):5829-32. 2. Leppä E, et al. Agonistic effects of the beta-carboline DMCM revealed in GABA(A) receptor gamma 2 subunit F77I point-mutated mice. Neuropharmacology. 2005 Mar;48(4):469-78.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Neurodegenerative Disease Compound Library Neurotransmitter Receptor Compound Library Bioactive Compound Library Bioactive Compounds Library Max Neuronal Signaling Compound Library

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Keywords

DMCM hydrochloride 1215833-62-7 Membrane transporter/Ion channel Neuroscience GABA Receptor DMCM Hydrochloride inhibitor inhibit

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