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DMCM hydrochloride

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Catalog No. T11061Cas No. 1215833-62-7

DMCM hydrochloride is a non-selective fully inverse agonist of benzodiazepine. DMCM showed significant differences in human recombinant GABAA αxβ3γ2 receptor subtypes. For α1, α2, α3, and α5 receptors, their Kis were 10 nM, 13 nM, 7.5 nM, 2.2 nM, respectively.

DMCM hydrochloride

DMCM hydrochloride

🥰Excellent
Purity: 98.95%
Catalog No. T11061Cas No. 1215833-62-7
DMCM hydrochloride is a non-selective fully inverse agonist of benzodiazepine. DMCM showed significant differences in human recombinant GABAA αxβ3γ2 receptor subtypes. For α1, α2, α3, and α5 receptors, their Kis were 10 nM, 13 nM, 7.5 nM, 2.2 nM, respectively.
Pack SizePriceAvailabilityQuantity
1 mg$31In Stock
2 mg$45In Stock
5 mg$77In Stock
10 mg$113In Stock
25 mg$263In Stock
50 mg$488In Stock
100 mg$689In Stock
1 mL x 10 mM (in DMSO)$85In Stock
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Purity:98.95%
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Product Introduction

Bioactivity
Description
DMCM hydrochloride is a non-selective fully inverse agonist of benzodiazepine. DMCM showed significant differences in human recombinant GABAA αxβ3γ2 receptor subtypes. For α1, α2, α3, and α5 receptors, their Kis were 10 nM, 13 nM, 7.5 nM, 2.2 nM, respectively.
Targets&IC50
GABAA α2 receptor:13 nM (ki), GABAA α3 receptor:7.5 nM (ki), GABAA α5  receptor:2.2 nM (ki), GABAA α1  receptor:ki:10 nM
In vivo
DMCM exhibits potent convulsant, proconvulsant, and anxiogenic properties in vivo. At doses of 20-60 mg/kg (i.p.), DMCM induces modest anxiolytic-like effects in γ2I77 mice[2].
Chemical Properties
Molecular Weight350.8
FormulaC17H19ClN2O4
Cas No.1215833-62-7
SmilesCl.CCc1c(ncc2[nH]c3cc(OC)c(OC)cc3c12)C(=O)OC
Relative Density.no data available
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
H2O: 22.5 mg/mL (64.1 mM), Sonication is recommended.
DMSO: 9 mg/mL (25.7 mM), Sonication is recommended.
Solution Preparation Table
DMSO/H2O
1mg5mg10mg50mg
1 mM2.8506 mL14.2531 mL28.5063 mL142.5314 mL
5 mM0.5701 mL2.8506 mL5.7013 mL28.5063 mL
10 mM0.2851 mL1.4253 mL2.8506 mL14.2531 mL
20 mM0.1425 mL0.7127 mL1.4253 mL7.1266 mL
H2O
1mg5mg10mg50mg
50 mM0.0570 mL0.2851 mL0.5701 mL2.8506 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
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