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Dabrafenib Mesylate
🥰Excellent
Catalog No. T8474Cas No. 1195768-06-9
Alias GSK2118436 Mesylate, GSK 2118436B
Dabrafenib Mesylate (GSK2118436 Mesylate) is a B-Raf inhibitor(IC50s of 0.6 and 5.0 nM for RafV600E and c-Raf, respectively).
Dabrafenib Mesylate
🥰Excellent
Purity: 99.62%
Catalog No. T8474Alias GSK2118436 Mesylate, GSK 2118436BCas No. 1195768-06-9
Dabrafenib Mesylate (GSK2118436 Mesylate) is a B-Raf inhibitor(IC50s of 0.6 and 5.0 nM for RafV600E and c-Raf, respectively).
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 5 mg | 38 € | In Stock | |
| 10 mg | 54 € | In Stock | |
| 25 mg | 68 € | In Stock | |
| 50 mg | 80 € | In Stock | |
| 100 mg | 111 € | In Stock | |
| 500 mg | 226 € | In Stock | |
| 1 mL x 10 mM (in DMSO) | 54 € | In Stock |
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Purity:99.62%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | Dabrafenib Mesylate (GSK2118436 Mesylate) is a B-Raf inhibitor(IC50s of 0.6 and 5.0 nM for RafV600E and c-Raf, respectively). |
| Targets&IC50 | Raf:5 nM, B-Raf (V600E):0.6 nM |
| In vitro | In human endothelial cells, Dabrafenib inhibits the release of HMGB1 and down-regulates the HMGB1-dependent inflammatory response by enhancing the expression of cell adhesion molecules (CAM)[1] |
| Alias | GSK2118436 Mesylate, GSK 2118436B |
| Molecular Weight | 615.67 |
| Formula | C24H24F3N5O5S3 |
| Cas No. | 1195768-06-9 |
| Smiles | CS(O)(=O)=O.CC(C)(C)c1nc(c(s1)-c1ccnc(N)n1)-c1cccc(NS(=O)(=O)c2c(F)cccc2F)c1F |
| Relative Density. | no data available |
Storage & Solubility Information
| Storage | keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 45 mg/mL (73.09 mM)  | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
DMSO
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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