Powder: -20°C for 3 years | In solvent: -80°C for 1 year
EBI-2511 is a highly potent and orally active inhibitor of EZH2 (IC50: 6 nM in Pfeffiera cell lines).
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 60.00 | |
5 mg | In stock | $ 147.00 | |
10 mg | In stock | $ 228.00 | |
25 mg | In stock | $ 478.00 | |
50 mg | In stock | $ 690.00 | |
100 mg | In stock | $ 992.00 |
Description | EBI-2511 is a highly potent and orally active inhibitor of EZH2 (IC50: 6 nM in Pfeffiera cell lines). |
Targets&IC50 | EZH2:6 nM (in cell) |
In vitro | EBI-2511 obviously decreases cellular H3K27me3 levels in a dose-dependent manner (an approximate IC50: 8 nM) and it is 3-fold more potent than EPZ-6438. In addition to Pfeffier cell line, EBI-2511 was shown active against WSU-DLCL2 ( IC50: 55 nM) [1]. |
In vivo | EBI-2511 shows a dose-dependent inhibition on the tumor growth, resulting in 28% (10mg/kg), 83% (30mg/kg), and 97% (100mg/kg) reduction in tumor size. There is no significant changes in body weights of all treatment groups are observed. At the same dosage level, EBI-2511 displays a superior anti-tumor efficacy to EPZ-6438 (P<0.01) [1]. |
Molecular Weight | 576.77 |
Formula | C34H48N4O4 |
CAS No. | 2098546-05-3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 5 mg/mL (8.67 mM), sonification is recommended.
You can also refer to dose conversion for different animals. More
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EBI-2511 2098546-05-3 Chromatin/Epigenetic Histone Methyltransferase Inhibitor inhibit EBI2511 EBI 2511 inhibitor