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Etelcalcetide hydrochloride

Catalog No. TP1236 CAS 1334237-71-6

Synonyms: KAI-4169 hydrochloride, AMG 416 hydrochloride

Etelcalcetide hydrochloride is a synthetic peptide as an allosteric modulator of the calcium (Ca)-sensing receptor (CaSR). Etelcalcetide hydrochloride is effective in lowering parathyroid hormone (PTH) concentrations in patients receiving dialysis with secondary hyperparathyroidism receiving hemodialysis.

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Etelcalcetide hydrochloride, CAS 1334237-71-6

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description

Synonyms	KAI-4169 hydrochloride, AMG 416 hydrochloride
Molecular Weight	1353.33
Formula	C38H73N21O10S2.17/2HCl
CAS No.	1334237-71-6

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

H2O: 10 mM

DMSO: Insoluble

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Block GA, et al. Effect of Etelcalcetide vs Cinacalcet on Serum Parathyroid Hormone in Patients Receiving Hemodialysis With Secondary Hyperparathyroidism: A Randomized Clinical Trial. JAMA. 2017 Jan 10;317(2):156-164.

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

Note:

Be sure to add the solvent(s) in order. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

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What is the mass of compound required to make a 10 mM stock solution in 10 ml of water given that the molecular weight of the compound is 197.13 g/mol?
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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Etelcalcetide hydrochloride 1334237-71-6 GPCR/G Protein CaSR KAI-4169 AMG416 KAI4169 KAI 4169 KAI-4169 hydrochloride AMG 416 inhibit Etelcalcetide AMG-416 Inhibitor Calcium-sensing receptor AMG 416 hydrochloride inhibitor

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