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Euphorbia factor L1

Catalog No. T2S0410 CAS 76376-43-7

Synonyms: Euphorbiasteroid

Euphorbia factor L1 (Euphorbiasteroid) can reduce Bcl-2, PI3K, AKT, and mTOR protein and mRNA levels, and up-regulate caspase-9 and caspase-3 protein levels. It induces autophagy and has anti-cancer, anti-adipogenic, anti-osteoclastogenic, and multidrug-resistant regulatory effects.

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Euphorbia factor L1, CAS 76376-43-7

Pack Size	Availability	Price/USD	Quantity
20 mg	In stock	$ 100.00
1 mL * 10 mM (in DMSO)	In stock	$ 80.00

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Purity: 99.74%

Purity: 98%

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Description	Euphorbia factor L1 (Euphorbiasteroid) can reduce Bcl-2, PI3K, AKT, and mTOR protein and mRNA levels, and up-regulate caspase-9 and caspase-3 protein levels. It induces autophagy and has anti-cancer, anti-adipogenic, anti-osteoclastogenic, and multidrug-resistant regulatory effects.
In vitro	Euphorbiasteroid suppresses adipogenic differentiation of 3T3‐L1 cells, mainly at the early stage, and stimulates the AMPK signalling pathway. The anti-adipogenic effects of euphorbiasteroid could possibly be attributed to activation of the AMPK pathway, by decreasing the level of FAS and its up-regulators, including C/EBPs, PPAR-γ and SREBP-1c, without involving insulin signalling pathway[1]. Euphorbiasteroid could be a transport substrate for P-gp that can effectively inhibit P-gp-mediated drug transport and reverse resistance to anticancer drugs in MES-SA/Dx5 cells[2].
Cell Research	3T3‐L1 cells were treated with euphorbiasteroid at concentrations of 6.25, 12.5, 25 and 50?μM for 2?days in adipogenesis induction medium, 2?days in adipogenesis medium and 2?days in culture medium (CM) sequentially during differentiation. Intracellular triglycerides (TGs) were stained with Oil red O (ORO) solution.
Source	Natural Products > Euphorbiaceae > Euphorbia

Synonyms	Euphorbiasteroid
Molecular Weight	552.66
Formula	C32H40O8
CAS No.	76376-43-7

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

Methanol: Soluble

DMSO: 37 mg/mL(66.9 mM)

Ethanol: Soluble

References and Literature

1. Park SJ, et al. Euphorbiasteroid, a component of Euphorbia lathyris L., inhibits adipogenesis of 3T3-L1 cells via activation of AMP-activated protein kinase.Cell Biochem Funct. 2015, 33(4):220-5. 2. Jung Sook Choi, et al. Euphorbiasteroid reverses P‐glycoprotein‐mediated multi‐drug resistance in human sarcoma cell line MES‐SA/Dx5.Phytotherapy research. 2010, 24(7):1042-1046.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Active Compound Library Membrane Protein-targeted Compound Library Natural Product Library NO PAINS Compound Library Anti-Tumor Natural Product Library PPI Inhibitor Library Ion Channel Inhibitor Library Macrocyclic Compound Library Covalent Inhibitor Library Terpene Natural Product Library

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Keywords

Euphorbia factor L1 76376-43-7 Apoptosis Membrane transporter/Ion channel Neuroscience P-gp Euphorbia factor L-1 Euphorbiasteroid inhibitor inhibit

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