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F1063-0967

Catalog No. T4308Cas No. 613225-56-2

F1063-0967 is a Dual-specificity phosphatase 26 (DUSP26) inhibitor with an IC50 of 11.62 μM.

F1063-0967

F1063-0967

Purity: 99.15%
Catalog No. T4308Cas No. 613225-56-2
F1063-0967 is a Dual-specificity phosphatase 26 (DUSP26) inhibitor with an IC50 of 11.62 μM.
Pack SizePriceAvailabilityQuantity
5 mg$30In Stock
10 mg$44In Stock
25 mg$77In Stock
50 mg$118In Stock
100 mg$173In Stock
200 mg$256In Stock
1 mL x 10 mM (in DMSO)$31In Stock
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Purity:99.15%
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Product Introduction

Bioactivity
Description
F1063-0967 is a Dual-specificity phosphatase 26 (DUSP26) inhibitor with an IC50 of 11.62 μM.
Targets&IC50
DUSP26:11.62 μM
In vitro
At concentration above 0.1 μM, F1063-0967 remarkably induces IMR32 cell apoptosis. F1063-0967 induces apoptosis in IMR-32 cell line with an IC50 value of 4.13 μM. F1063-0967 has no effect on HL7702 cell line, and little inhibition effect on SH-SY5Y cell line.
Cell Research
The IMR-32 cells are plated in 96-well plates with 1×103 cells per well. After the cells are allowed to settle for 24 h, F1063-0967 (0, 10, 1, and 0.1 μM) is added. An MTTassay is performed. For cell lines HL7702 and SH-SY5Y, the cells are allowed to settle for 24 h, F1063-0967 (10 μM) is added, then MTT assays are carried out after 72 h.
Chemical Properties
Molecular Weight484.59
FormulaC24H24N2O5S2
Cas No.613225-56-2
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 60 mg/mL (123.82 mM)
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.0636 mL10.3180 mL20.6360 mL103.1800 mL
5 mM0.4127 mL2.0636 mL4.1272 mL20.6360 mL
10 mM0.2064 mL1.0318 mL2.0636 mL10.3180 mL
20 mM0.1032 mL0.5159 mL1.0318 mL5.1590 mL
50 mM0.0413 mL0.2064 mL0.4127 mL2.0636 mL
100 mM0.0206 mL0.1032 mL0.2064 mL1.0318 mL

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Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
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