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Firsocostat

Catalog No. T7184 CAS 1434635-54-7

Synonyms: ND-630, GS-0976, NDI-010976

ND-630 is an inhibitor of acetyl-CoA carboxylase (ACC) dimerization that inhibits human ACC1 and ACC2 activity (IC50s of 2.1 and 6.1 nM, respectively)

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Firsocostat, CAS 1434635-54-7

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Purity: 98%

Biological Description

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Storage & Solubility Information

Description	ND-630 is an inhibitor of acetyl-CoA carboxylase (ACC) dimerization that inhibits human ACC1 and ACC2 activity (IC50s of 2.1 and 6.1 nM, respectively)
Targets&IC50	ACC2:6.1 nM, ACC1:2.1 nM
In vitro	ND-630 inhibited hACC1 with an IC50 of 2.1 ± 0.2 nM and hACC2 with an IC50 of 6.1 ± 0.8 nM .?Inhibition was reversible and highly specific for ACC, as evidenced by the absence of an effect of ND-630 on the activity of 101 enzymes, receptors, growth factors, transporters, and ion channels of the Ricerca DrugMatrix Panel at 10 μM .?In addition, because the ACC dimerization site is not conserved among the mammalian carboxylases , ND-630 lacks the ability to inhibit any of these mechanistically related enzymes and therefore exhibits absolute specificity for ACC inhibition relative to other mammalian carboxylases.
In vivo	ND-630 reduces hepatic steatosis in a rat model of diet-induced obesity and in Zucker diabetic rats. It also improves insulin secretion stimulated by glucose and reduces hemoglobin A1c levels by 0.9% in Zucker diabetic rats.

Synonyms	ND-630, GS-0976, NDI-010976
Molecular Weight	569.63
Formula	C28H31N3O8S
CAS No.	1434635-54-7

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 50 mg/mL (87.78 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Harriman G , Greenwood J , Bhat S , et al. Acetyl-CoA carboxylase inhibition by ND-630 reduces hepatic steatosis, improves insulin sensitivity, and modulates dyslipidemia in rats[J]. Proceedings of the National Academy of Sciences, 2016:201520686.

Citations

1. Li M, Yang J, Ye C, et al. Integrated Metabolomics and Transcriptomics Analyses Reveal Metabolic Landscape in Neuronal Cells during JEV Infection. Virologica Sinica. 2021: 1-12.

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Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Firsocostat 1434635-54-7 Metabolism Acetyl-CoA Carboxylase ND 630 ND-630 NDI 010976 inhibit GS-0976 NDI-010976 NDI010976 ACC, Acetyl Coenzyme A Carboxylase GS 0976 ND630 Inhibitor GS0976 inhibitor

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