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G-1

G-1
G-1 is a nonsteroidal, high-affinity, and selective GPR30 agonist (Ki: 11 nM).
Catalog No. T15364Cas No. 881639-98-1
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Purity:98.94%
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G-1

Catalog No. T15364Cas No. 881639-98-1
G-1 is a nonsteroidal, high-affinity, and selective GPR30 agonist (Ki: 11 nM).
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
Pack SizePriceAvailabilityQuantity
1 mg$43In Stock
5 mg$80In Stock
10 mg$126In Stock
25 mg$223In Stock
50 mg$369In Stock
100 mg$531In Stock
1 mL x 10 mM (in DMSO)$75In Stock
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Product Introduction

Bioactivity
Description
G-1 is a nonsteroidal, high-affinity, and selective GPR30 agonist (Ki: 11 nM).
Targets&IC50
GPR30:(ki)11 nM
In vitro
Treatment with G-1 (10 μM and 100 μM; 48 and 72 h) obviously reduces cell proliferation (P<0.001). At 72 h, the IC50 value for G-1 is calculated to be 20 μM. Cell cycle analysis of H295R cells after 24 h of G-1 treatment shows a cell cycle arrest in the G2 phase. Treatment of A549 cells with G-1(20 μM) reveals a significant increase in apoptosis, consistent with its antiproliferative effect (P<0.001)[2]. The presence of G-1 increases Bax expression while reduces Bcl-2[3].
In vivo
After 14 days post-injury, the results display that the Basso mouse scale scores are obviously higher in the G-1 group compared with the other groups (P<0.05). G-1 administration produces a statistically significant induce in tumor volume from day 14 post-treatment. Grafted tumors harvested after a three-week treatment with G-1 show a significant decrease in tumor weight compare to vehicle-treated animals[3]. The number of caspase-3-positive cells in the cross-sections is counted, and G-1 group has fewer positive cells compared with the other groups (P<0.05), and there is no difference between the two groups (P>0.05)[1].
Chemical Properties
Molecular Weight412.28
FormulaC21H18BrNO3
Cas No.881639-98-1
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
H2O: < 0.1 mg/mL (insoluble)
DMSO: 50 mg/mL (121.28 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.4255 mL12.1277 mL24.2554 mL121.2768 mL
5 mM0.4851 mL2.4255 mL4.8511 mL24.2554 mL
10 mM0.2426 mL1.2128 mL2.4255 mL12.1277 mL
20 mM0.1213 mL0.6064 mL1.2128 mL6.0638 mL
50 mM0.0485 mL0.2426 mL0.4851 mL2.4255 mL
100 mM0.0243 mL0.1213 mL0.2426 mL1.2128 mL

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Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
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