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G15

Catalog No. T7389 CAS 1161002-05-6

G15 is a cell-permeable non-steroidal antagonist of GPER (Ki = 20 nM)

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G15, CAS 1161002-05-6

Pack Size	Availability	Price/USD
1 mg	In stock	$ 33.00
5 mg	In stock	$ 75.00
10 mg	In stock	$ 125.00
25 mg	In stock	$ 228.00
50 mg	In stock	$ 389.00
100 mg	In stock	$ 585.00
1 mL * 10 mM (in DMSO)	In stock	$ 83.00

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Biological Description

Chemical Properties

Storage & Solubility Information

Description	G15 is a cell-permeable non-steroidal antagonist of GPER (Ki = 20 nM)
Targets&IC50	GPER:20 nM(Ki)
In vivo	G-15 antagonizes the anti-depressive effects of estrogen in vivo[1].
Animal Research	G15 and G1 were first dissolved in DMSO and diluted with saline; the final concentration in DMSO was 1 mM. Desipramine and E2 (cyclodextrin-encapsulated, 4-5.5% E2) were dissolved in saline solution and DMSO was added to a final concentration of 1 mM. An appropriate vehicle-treated group (saline with 1 mM DMSO) was included as a control (sham). All solutions were freshly prepared before each experimental series. Independent groups of mice (n=12-16) were treated with two consecutive intraperitoneal injections as follows: vehicle solution + vehicle solution (sham group); vehicle + G-1 (indicated amount in nmol); vehicle + desipramine (10mg/kg); G15 (10nmol/mouse) + desipramine (10mg/kg); G15 (10nmol/mouse) + G-1 (1nmol/mouse); vehicle + G15 (10nmol/mouse); vehicle + soluble E2 (5 mg/kg); G15 (25nmol/mouse) + soluble E2 (5 mg/kg). The second compound was injected 15 min (7 min for E2) after the first injection and the tail suspension test performed 30 min after the second injection[1].

Molecular Weight	370.24
Formula	C19H16BrNO2
CAS No.	1161002-05-6

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 41.67 mg/mL (112.55 mM)

References and Literature

1. Nayak T K , Bologa C G , Leitao A , et al. In vivo effects of a GPR30 antagonist[J]. Nature Chemical Biology, 2009, 5(6):421-427. 2. Bai L Y , Weng J R , Hu J L , et al. G15, a GPR30 antagonist, induces apoptosis and autophagy in human oral squamous carcinoma cells[J]. Chemico-Biological Interactions, 2013, 206(2):375-384.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Bioactive Compound Library Bioactive Compounds Library Max Endocrinology-Hormone Compound Library Nuclear Receptor Compound Library Anti-Ovarian Cancer Compound Library Anti-Cancer Compound Library

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

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Keywords

G15 1161002-05-6 Endocrinology/Hormones Estrogen Receptor/ERR Inhibitor inhibit G-15 G 15 inhibitor

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