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GC7 Sulfate

Catalog No. T11372Cas No. 150417-90-6

GC7 Sulfate is a potent inhibitor of deoxyhypusine synthase (DHS). Eukaryotic translation initiation factor 5A2 (eIF5A2) is the only known substrate for DHS, so GC7 inhibits the activation of eIF5A2 by inhibiting DHS activity.

GC7 Sulfate

GC7 Sulfate

Purity: 100%
Catalog No. T11372Cas No. 150417-90-6
GC7 Sulfate is a potent inhibitor of deoxyhypusine synthase (DHS). Eukaryotic translation initiation factor 5A2 (eIF5A2) is the only known substrate for DHS, so GC7 inhibits the activation of eIF5A2 by inhibiting DHS activity.
Pack SizePriceAvailabilityQuantity
5 mg$47In Stock
10 mg$89In Stock
25 mg$197In Stock
50 mg$297In Stock
100 mg$478In Stock
500 mg$1,050In Stock
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Purity:100%
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Product Introduction

Bioactivity
Description
GC7 Sulfate is a potent inhibitor of deoxyhypusine synthase (DHS). Eukaryotic translation initiation factor 5A2 (eIF5A2) is the only known substrate for DHS, so GC7 inhibits the activation of eIF5A2 by inhibiting DHS activity.
Targets&IC50
S1P1:10 nM(ki)
In vitro
Cell cycle analysis show that GC7 Sulfate reduces the CHO-K1 cell population in the G1-phase of the cell cycle by 42% and increases the number of cells in the S-phase by 44%. Furthermore, GC7 Sulfate inhibited the growth of H9 cells in a concentration-dependent manner. While 1 μM GC7 Sulfate had no significant effect on H9 cell proliferation, inhibition of growth became evident with 3 μM GC7 Sulfate. At 10 μM GC7 Sulfate, H9 cell growth was completely blocked within 1 or 2 days after the addition of the drug[1].
Chemical Properties
Molecular Weight270.35
FormulaC8H22N4O4S
Cas No.150417-90-6
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
H2O: 2.7 mg/mL (10.0 mM), Sonication and heating are recommended.
DMSO: < 1 mg/mL (insoluble)
Solution Preparation Table
H2O
1mg5mg10mg50mg
1 mM3.6989 mL18.4945 mL36.9891 mL184.9454 mL
5 mM0.7398 mL3.6989 mL7.3978 mL36.9891 mL
10 mM0.3699 mL1.8495 mL3.6989 mL18.4945 mL

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