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GC7 Sulfate is a potent inhibitor of deoxyhypusine synthase (DHS). Eukaryotic translation initiation factor 5A2 (eIF5A2) is the only known substrate for DHS, so GC7 inhibits the activation of eIF5A2 by inhibiting DHS activity.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
5 mg | $47 | In Stock | |
10 mg | $89 | In Stock | |
25 mg | $197 | In Stock | |
50 mg | $297 | In Stock | |
100 mg | $478 | In Stock | |
500 mg | $1,050 | In Stock |
Description | GC7 Sulfate is a potent inhibitor of deoxyhypusine synthase (DHS). Eukaryotic translation initiation factor 5A2 (eIF5A2) is the only known substrate for DHS, so GC7 inhibits the activation of eIF5A2 by inhibiting DHS activity. |
Targets&IC50 | S1P1:10 nM(ki) |
In vitro | Cell cycle analysis show that GC7 Sulfate reduces the CHO-K1 cell population in the G1-phase of the cell cycle by 42% and increases the number of cells in the S-phase by 44%. Furthermore, GC7 Sulfate inhibited the growth of H9 cells in a concentration-dependent manner. While 1 μM GC7 Sulfate had no significant effect on H9 cell proliferation, inhibition of growth became evident with 3 μM GC7 Sulfate. At 10 μM GC7 Sulfate, H9 cell growth was completely blocked within 1 or 2 days after the addition of the drug[1]. |
Molecular Weight | 270.35 |
Formula | C8H22N4O4S |
Cas No. | 150417-90-6 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||
Solubility Information | H2O: 2.7 mg/mL (10.0 mM), Sonication and heating are recommended. DMSO: < 1 mg/mL (insoluble) | ||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||
H2O
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