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Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $41 | In Stock | |
2 mg | $59 | In Stock | |
5 mg | $97 | In Stock | |
10 mg | $155 | In Stock | |
25 mg | $253 | In Stock | |
50 mg | $356 | In Stock | |
100 mg | $529 | In Stock | |
1 mL x 10 mM (in DMSO) | $97 | In Stock |
Description | GFB-8438 is a potent and subtype selective inhibitor of TRPC5(IC50s of 0.18 and 0.29 μM of hTRPC5 and hTRPC4, respectively). |
In vitro | GFB-8438 is a novel TRPC5 inhibitor. GFB-8438 protects mouse podocytes from injury induced by protamine sulfate (PS) in vitro. |
In vivo | GFB-8438is also efficacious in a hypertensive deoxycorticosterone acetate (DOCA)-salt rat model of FSGS, significantly reducing both total protein and albumin concentrations in urine |
Animal Research | Sprague Dawley rats (DOCA-salt rat model of FSGS);30 mg/kg; Administration:s.c.; daily for 3 weeks |
Molecular Weight | 386.76 |
Formula | C16H14ClF3N4O2 |
Cas No. | 2304549-73-1 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | ||||||||||||||||||||||||||||||
Solubility Information | DMSO: 27.5 mg/mL (71.1 mM) ![]() | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
DMSO
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