Powder: -20°C for 3 years | In solvent: -80°C for 1 year
GNE-6640 is a non-covalent inhibitor targeting ubiquitin specific peptidase 7 (USP7), exhibiting IC50 values of 0.75 μM for full-length USP7, 0.43 μM for the USP7 catalytic domain, 20.3 μM for full-length USP43, and 0.23 μM for Ub-MDM2, respectively.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 64.00 | |
2 mg | In stock | $ 93.00 | |
5 mg | In stock | $ 155.00 | |
10 mg | In stock | $ 263.00 | |
25 mg | In stock | $ 563.00 | |
50 mg | In stock | $ 812.00 | |
100 mg | In stock | $ 1,130.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 169.00 |
Description | GNE-6640 is a non-covalent inhibitor targeting ubiquitin specific peptidase 7 (USP7), exhibiting IC50 values of 0.75 μM for full-length USP7, 0.43 μM for the USP7 catalytic domain, 20.3 μM for full-length USP43, and 0.23 μM for Ub-MDM2, respectively. |
Targets&IC50 | Ub-MDM2:0.23 μM, USP7 catalytic domain:0.43 μM , USP7 (full length):0.75 μM , USP43 (full length):20.3 μM |
In vitro | GNE-6640 facilitates the promotion of endogenous MDM2 ubiquitination utilizing Lys48 (K48)-linked polyubiquitin chains leading to its proteasomal degradation. This compound specifically acts on cellular USP7, MDM2, and p53 signaling pathways, reducing the viability of 108 cell lines with IC50 values of ≤ 10 μM. When combined with DNA-damaging agents like doxorubicin or cisplatin, GNE-6640 activates the p53 response, thereby enhancing USP7 inhibitor efficacy and inducing tumor cell death. Furthermore, GNE-6640 augments cytotoxicity when used alongside various chemotherapeutic agents and targeted compounds, such as PIM kinase inhibitors, showcasing its potential as a versatile adjunct in cancer therapy. |
Molecular Weight | 330.38 |
Formula | C20H18N4O |
CAS No. | 2009273-67-8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 5 mg/mL (15.13 mM)
You can also refer to dose conversion for different animals. More
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GNE-6640 2009273-67-8 Cell Cycle/Checkpoint DNA Damage/DNA Repair Ubiquitination DUB Deubiquitinase DUBs inhibit Inhibitor GNE 6640 GNE6640 inhibitor