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GSK2801

Catalog No. T2436 CAS 1619994-68-1

GSK2801 is an effective, specific and cell active acetyl-lysine competitive inhibitor of BAZ2A(Kd: 136 nM) and BAZ2B(Kd: 257 nM) bromodomains.

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GSK2801, CAS 1619994-68-1

Pack Size	Availability	Price/USD
2 mg	In stock	$ 39.00
5 mg	In stock	$ 60.00
10 mg	In stock	$ 79.00
25 mg	In stock	$ 180.00
50 mg	In stock	$ 323.00
100 mg	In stock	$ 538.00
1 mL * 10 mM (in DMSO)	In stock	$ 63.00

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Purity: 99.88%

Purity: 99.5%

Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	GSK2801 is an effective, specific and cell active acetyl-lysine competitive inhibitor of BAZ2A(Kd: 136 nM) and BAZ2B(Kd: 257 nM) bromodomains.
Targets&IC50	BAZ2A:257 nM(Kd), BAZ2B:136 nM(Kd)
In vitro	In U2OS cells transfected with mutant BAZ2A (N1873F), GSK2801 (1 μM) accelerates FRAP half-recovery time by displacing BAZ2A from chromatin. [1]
In vivo	In male CD1 mice, GSK2801 (30 mg/kg, p.o. and i.p.) has reasonable in vivo exposure after oral dosing, modest clearance, and reasonable plasma stability. [1]

Molecular Weight	371.45
Formula	C20H21NO4S
CAS No.	1619994-68-1

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 18.6 mg/mL (50 mM)

References and Literature

1. Chen P, et al. 2015. DOI: 10.1021/acs.jmedchem.5b00209

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Epigenetics Compound Library Histone Modification Compound Library NO PAINS Compound Library Orally Active Compound Library Bioactive Compound Library Bioactive Compounds Library Max Anti-Aging Compound Library Reprogramming Compound Library Chromatin Modification Compound Library

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

GSK2801 1619994-68-1 Apoptosis Chromatin/Epigenetic Epigenetic Reader Domain inhibit GSK 2801 Inhibitor TNBC BAZ2A GSK-2801 BAZ2B cetyl-lysine orally inhibitor

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