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Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $39 | In Stock | |
2 mg | $54 | In Stock | |
5 mg | $84 | In Stock | |
10 mg | $133 | In Stock | |
25 mg | $226 | In Stock | |
50 mg | $397 | In Stock | |
100 mg | $597 | In Stock | |
1 mL x 10 mM (in DMSO) | $97 | In Stock |
Description | GSK8612 is a highly selective and potent inhibitor of Tank-binding Kinase-1 (TBK1, pIC50: 6.8). |
Targets&IC50 | TBK1:6.8 (pIC50) |
In vitro | In cellular assays, GSK8612 inhibited toll-like receptor (TLR)3-induced interferon regulatory factor (IRF)3 phosphorylation in Ramos cells and type I interferon (IFN) secretion in primary human mononuclear cells. In THP1 cells, GSK8612 was able to inhibit secretion of interferon-beta (IFNβ) in response to dsDNA and cGAMP, the natural ligand for STING. |
Molecular Weight | 520.33 |
Formula | C17H17BrF3N7O2S |
Cas No. | 2361659-62-1 |
Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
Solubility Information | H2O: Insoluble DMSO: 100 mg/mL (192.19 mM) | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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