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GSK8612

GSK8612
GSK8612 is a highly selective and potent inhibitor of Tank-binding Kinase-1 (TBK1, pIC50: 6.8).
Catalog No. T5540Cas No. 2361659-62-1
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Purity:99.8%
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GSK8612

Purity: 99.8%
Catalog No. T5540Cas No. 2361659-62-1

GSK8612 is a highly selective and potent inhibitor of Tank-binding Kinase-1 (TBK1, pIC50: 6.8).
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
Pack SizePriceAvailabilityQuantity
1 mg$39In Stock
2 mg$54In Stock
5 mg$84In Stock
10 mg$133In Stock
25 mg$226In Stock
50 mg$397In Stock
100 mg$597In Stock
1 mL x 10 mM (in DMSO)$97In Stock
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Product Introduction

Bioactivity
Description
GSK8612 is a highly selective and potent inhibitor of Tank-binding Kinase-1 (TBK1, pIC50: 6.8).
Targets&IC50
TBK1:6.8 (pIC50)
In vitro
In cellular assays, GSK8612 inhibited toll-like receptor (TLR)3-induced interferon regulatory factor (IRF)3 phosphorylation in Ramos cells and type I interferon (IFN) secretion in primary human mononuclear cells. In THP1 cells, GSK8612 was able to inhibit secretion of interferon-beta (IFNβ) in response to dsDNA and cGAMP, the natural ligand for STING.
Chemical Properties
Molecular Weight520.33
FormulaC17H17BrF3N7O2S
Cas No.2361659-62-1
Storage & Solubility Information
Storagestore at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
H2O: Insoluble
DMSO: 100 mg/mL (192.19 mM)
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM1.9219 mL9.6093 mL19.2186 mL96.0929 mL
5 mM0.3844 mL1.9219 mL3.8437 mL19.2186 mL
10 mM0.1922 mL0.9609 mL1.9219 mL9.6093 mL
20 mM0.0961 mL0.4805 mL0.9609 mL4.8046 mL
50 mM0.0384 mL0.1922 mL0.3844 mL1.9219 mL
100 mM0.0192 mL0.0961 mL0.1922 mL0.9609 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
1 Enter information below:
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2 Enter the in vivo formulation:
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