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HOMOPLANTAGININ

Catalog No. T4S0217 CAS 17680-84-1

Homoplantaginin is a flavonoid from a traditional Chinese medicine Salvia plebeia,it has a protective and therapeutic effect on hepatocyte injury and shows potent inhibitory activities against influenza.

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HOMOPLANTAGININ, CAS 17680-84-1

Pack Size	Availability	Price/USD
1 mg	In stock	$ 32.00
5 mg	In stock	$ 72.00
10 mg	In stock	$ 113.00
25 mg	In stock	$ 239.00
50 mg	In stock	$ 396.00
100 mg	In stock	$ 567.00
1 mL * 10 mM (in DMSO)	In stock	$ 74.00

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Purity: 99.6%

Purity: 99.2%

Purity: 97.63%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Homoplantaginin is a flavonoid from a traditional Chinese medicine Salvia plebeia,it has a protective and therapeutic effect on hepatocyte injury and shows potent inhibitory activities against influenza.
In vitro	Homoplantaginin may be used for the prevention and treatment of endothelial dysfunction associated with insulin resistance, it ameliorates endothelial insulin resistance by inhibiting inflammation and modulating cell signalling via the IKKβ/IRS-1/pAkt/peNOS pathway.
In vivo	Homoplantaginin displayed an antioxidant property in a cell-free system and showed IC(50) of reduction level of DPPH radical at 0.35 microg/ml. In human hepatocyte HL-7702 cells exposed to H(2)O(2), the addition of 0.1-100 microg/ml of Homoplantaginin, which did not have a toxic effect on cell viability, significantly reduced lactate dehydrogenase (LDH) leakage, and increased glutathione (GSH), glutathione peroxidase (GSH-Px) and superoxide dismutase (SOD) in supernatant. In vivo assay, we employed the model of Bacillus Calmette-Guérin (BCG)/lipopolysaccharide (LPS)-induced hepatic injury mice to evaluate efficacy of Homoplantaginin. Homoplantaginin (25-100mg/kg) significantly reduced the increase in serum alanine aminotranseferase (ALT) and aspartate aminotransferase (AST), decreased the levels of tumor necrosis factor-alpha (TNF-alpha) and interleukin-1 (IL-1). The same treatment also reduced the content of thiobarbituric acid-reactive substances (TBARS), elevated the levels of GSH, GSH-Px and SOD in hepatic homogenate. The histopathological analysis showed that the grade of liver injury was ameliorated with reduction of inflammatory cells and necrosis of liver cells in Homoplantaginin treatment mice.
Source	Natural Products > Lamiaceae > Salvia

Molecular Weight	462.4
Formula	C22H22O11
CAS No.	17680-84-1

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 100 mg/mL (216.26 mM)

References and Literature

1. Qu X J , Xia X , Wang Y S , et al. Protective effects of Salvia plebeia compound homoplantaginin on hepatocyte injury[J]. Food & Chemical Toxicology, 2009, 47(7):0-1715.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library NO PAINS Compound Library Anti-Pancreatic Cancer Compound Library Immunology/Inflammation Compound Library Anti-Cancer Compound Library HIF-1 Signaling Pathway Compound Library Traditional Chinese Medicine Monomer Library Natural Product Library Ferroptosis Compound Library Oxidation-Reduction Compound Library

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Keywords

HOMOPLANTAGININ 17680-84-1 Apoptosis NF-Κb NF-κB TNF inhibit Inhibitor TNFR TNF Receptor Nuclear factor-κB Tumor Necrosis Factor Receptor Nuclear factor-kappaB inhibitor

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