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Hydroxycitric acid tripotassium hydrate

Catalog No. T11589 CAS 6100-05-6

Synonyms: Potassium citrate monohydrate

Hydroxycitric acid tripotassium hydrate (Potassium citrate monohydrate) effectively inhibits stones formation and also inhibits HIF, and has antioxidation, anti-inflammation, and anti-tumor effects. Hydroxycitric acid tripotassium hydrate(Potassium citrate monohydrate) (Potassium citrate monohydrate) is the major active ingredient of Garcinia cambogia and a derivative of citric acid. Hydroxycitric acid tripotassium hydrate(Potassium citrate monohydrate) competitively inhibits ATP citrate lyase with weight loss benefits.

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Hydroxycitric acid tripotassium hydrate Chemical Structure

Hydroxycitric acid tripotassium hydrate, CAS 6100-05-6

Pack Size	Availability	Price/USD
100 mg	In stock	$ 31.00
500 mg	In stock	$ 76.00
1 mL * 10 mM (in DMSO)	In stock	$ 50.00

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Purity: 95%

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Description	Hydroxycitric acid tripotassium hydrate (Potassium citrate monohydrate) effectively inhibits stones formation and also inhibits HIF, and has antioxidation, anti-inflammation, and anti-tumor effects. Hydroxycitric acid tripotassium hydrate(Potassium citrate monohydrate) (Potassium citrate monohydrate) is the major active ingredient of Garcinia cambogia and a derivative of citric acid. Hydroxycitric acid tripotassium hydrate(Potassium citrate monohydrate) competitively inhibits ATP citrate lyase with weight loss benefits.
In vitro	Hydroxycitric acid suppresses HIF-1α protein expression increased by CoCl2 administration in ARPE19 cells and 661W cells. Hydroxycitric acid decreases the accumulation of lipid droplets and accelerated energy metabolism in chicken hepatocytes. Hydroxycitric acid protects the cells from ER stress by increasing the antioxidant status and mitochondrial functions.Hydroxycitric acid shows an HIF inhibitory effect compared with the control group in ARPE19 cells and 661W cells. Hydroxycitric acid can downregulate Hif1a and the downstream genes in ARPE19 cells and 661W cells.
In vivo	Hydroxycitric acid attenuates the oxidative stress induced by calcium oxalate crystallization. Hydroxycitric acid has inhibitory effects on calcium oxalate-induced inflammatory cytokines, such as MCP-1, IL-1 β, and IL-6. Moreover, Hydroxycitric acid alleviates tubular injury and apoptosis caused by calcium oxalate crystals. The administration of Hydroxycitric acid can suppress body weight gain and fat accumulation in animals. Hydroxycitric acid (100-200 mg/kg) treatment could reduce markers of renal impairment (Blood Urea Nitrogen and serum creatinine). Calcium oxalate crystal deposition in mice (male C57BL/6J mice) treated with Hydroxycitric acid is significantly decreased.

Synonyms	Potassium citrate monohydrate
Molecular Weight	324.41
Formula	C6H7K3O8
CAS No.	6100-05-6

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 2.49 mg/mL (10 mM)

References and Literature

1. Liu X, et al. Hydroxycitric acid inhibits renal calcium oxalate deposition by reducing oxidative stress and inflammation. Curr Mol Med. 2020 Jan 3. 2. Ibuki M, et al. Therapeutic Effect of Garcinia cambogia Extract and Hydroxycitric Acid Inhibiting Hypoxia-Inducible Factor in a Murine Model of Age-Related Macular Degeneration. Int J Mol Sci. 2019 Oct 11;20(20). pii: E5049. 3. Han S, et al. Hydroxycitric Acid Tripotassium Inhibits Calcium Oxalate Crystal Formation in the Drosophila Melanogaster Model of Hyperoxaluria. Med Sci Monit. 2019 May 17;25:3662-3667. 4. Heymsfield SB, et al. Garcinia cambogia (hydroxycitric acid) as a potential antiobesity agent: a randomized controlled trial. JAMA. 1998 Nov 11;280(18):1596-600.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Anti-Cancer Drug Library Tobacco Monomer Library Anti-Cancer Clinical Compound Library Drug Repurposing Compound Library Anti-Cancer Active Compound Library Bioactive Compound Library Oxidation-Reduction Compound Library Natural Product Library for HTS Anti-Cancer Compound Library

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Related compounds with same targets

Forrestiacids K Forrestiacids J MEDICA16 (-)-Hydroxycitric acid lactone 2-Furoic acid (-)-Hydroxycitric acid NDI-091143 Bempedoic acid

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Keywords

Hydroxycitric acid tripotassium hydrate 6100-05-6 Angiogenesis Chromatin/Epigenetic Metabolism HIF/HIF Prolyl-Hydroxylase HIF ATP Citrate Lyase CaOx stones HIF-1α cleavage anti-inflammation HIF-PH Citrate HIFs ACLY 1534146 inhibit Hydroxycitric acid tripotassium Hydrate Inhibitor Hydroxycitric acid tripotassium Potassium citrate Monohydrate extramitochondrial Hypoxia-inducible factors antioxidation ATP safety Potassium citrate Potassium citrate monohydrate Potassium Citrate Bacterial inhibitor

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