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INF39

Catalog No. T4217Cas No. 866028-26-4

INF39 is a noncytotoxic and irreversible NLRP3 inhibitor.

INF39

INF39

Purity: 99.78%
Catalog No. T4217Cas No. 866028-26-4
INF39 is a noncytotoxic and irreversible NLRP3 inhibitor.
Pack SizePriceAvailabilityQuantity
1 mg$56In Stock
2 mg$79In Stock
5 mg$122In Stock
10 mg$172In Stock
25 mg$363In Stock
50 mg$543In Stock
100 mg$783In Stock
500 mg$1,620In Stock
1 mL x 10 mM (in DMSO)$143In Stock
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Purity:99.78%
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Product Introduction

Bioactivity
Description
INF39 is a noncytotoxic and irreversible NLRP3 inhibitor.
In vitro
INF39 possibly reacts with Cys-SH residues in the active site of cysteine protease caspase-1 but does not directly inhibit caspase-1 activity. INF39 (10 μM) can markedly inhibit ATP- and nigericin-induced IL-1β release. In the macrophages, INF39 suppresses caspase-1 activation and pyroptosis. INF39 can also block the NF-κB pathway. INF39 can reduce the steady-state (or basal) BRET signal of NLRP3, and not affect the viability of cells. INF39 cannot affect the initial conformational changes suffered by NLRP3 upon sensing the decrease of intracellular K+, but it affects the second step of NLRP3 conformational change. INF39 reaches the intestinal epithelium without undergoing chemical modifications. It is likely to act locally at the mucosal epithelial level after absorption into epithelial cells.
In vivo
INF39 (p.o.) reduces systemic and colonic inflammation in rats treated with 2,4- dinitrobenzene sulfonic acid. In inflamed rats, INF39 (12.5/25/50 mg/ kg) markedly increases body weight. DNBS causes a significant increment of spleen weight (+39.3%). This increase is markedly reduced by administration of INF39 (+2.2, +4.3 and +4.8% at 12.5, 25, 50 mg/kg, respectively). The inhibition of NLRP3 inflammasome complex with INF39 can dose-dependently attenuate the decrease in colonic length (?19, ?13 and ?8% at 12.5, 25, 50 mg/kg, respectively). Rats treated with INF39 shows a significant reduction of macroscopic damage score (4.7 at 12.5 mg/kg, 3.1 at 25 mg/kg, and 2.8 at 50 mg/kg).
Cell Research
Human THP-1 cells were exposed to INF39 (0.1?100 μM, 72 h), and then cell viability was evaluated by the MTT assay.
Animal Research
Animal Models: Male Sprague?Dawley rats. Solvent: olive oil. Dosages: 12.5,25.0,50.0 mg/kg/day,p.o.
Chemical Properties
Molecular Weight224.68
FormulaC12H13ClO2
Cas No.866028-26-4
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 10 mg/mL (44.51 mM)
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM4.4508 mL22.2539 mL44.5077 mL222.5387 mL
5 mM0.8902 mL4.4508 mL8.9015 mL44.5077 mL
10 mM0.4451 mL2.2254 mL4.4508 mL22.2539 mL
20 mM0.2225 mL1.1127 mL2.2254 mL11.1269 mL

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