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INF39

Catalog No. T4217 CAS 866028-26-4

INF39 is a noncytotoxic and irreversible NLRP3 inhibitor.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

INF39, CAS 866028-26-4

Pack Size	Availability	Price/USD
1 mg	In stock	$ 56.00
2 mg	In stock	$ 79.00
5 mg	In stock	$ 122.00
10 mg	In stock	$ 172.00
25 mg	In stock	$ 363.00
50 mg	In stock	$ 543.00
100 mg	In stock	$ 783.00
500 mg	In stock	$ 1,620.00
1 mL * 10 mM (in DMSO)	In stock	$ 143.00

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Purity: 99.78%

Purity: 99.67%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	INF39 is a noncytotoxic and irreversible NLRP3 inhibitor.
In vitro	INF39 possibly reacts with Cys-SH residues in the active site of cysteine protease caspase-1 but does not directly inhibit caspase-1 activity. INF39 (10 μM) can markedly inhibit ATP- and nigericin-induced IL-1β release. In the macrophages, INF39 suppresses caspase-1 activation and pyroptosis. INF39 can also block the NF-κB pathway. INF39 can reduce the steady-state (or basal) BRET signal of NLRP3, and not affect the viability of cells. INF39 cannot affect the initial conformational changes suffered by NLRP3 upon sensing the decrease of intracellular K+, but it affects the second step of NLRP3 conformational change. INF39 reaches the intestinal epithelium without undergoing chemical modifications. It is likely to act locally at the mucosal epithelial level after absorption into epithelial cells.
In vivo	INF39 (p.o.) reduces systemic and colonic inflammation in rats treated with 2,4- dinitrobenzene sulfonic acid. In inflamed rats, INF39 (12.5/25/50 mg/ kg) markedly increases body weight. DNBS causes a significant increment of spleen weight (+39.3%). This increase is markedly reduced by administration of INF39 (+2.2, +4.3 and +4.8% at 12.5, 25, 50 mg/kg, respectively). The inhibition of NLRP3 inflammasome complex with INF39 can dose-dependently attenuate the decrease in colonic length (?19, ?13 and ?8% at 12.5, 25, 50 mg/kg, respectively). Rats treated with INF39 shows a significant reduction of macroscopic damage score (4.7 at 12.5 mg/kg, 3.1 at 25 mg/kg, and 2.8 at 50 mg/kg).
Cell Research	Human THP-1 cells were exposed to INF39 (0.1?100 μM, 72 h), and then cell viability was evaluated by the MTT assay.
Animal Research	Animal Models: Male Sprague?Dawley rats. Solvent: olive oil. Dosages: 12.5,25.0,50.0 mg/kg/day,p.o.

Molecular Weight	224.68
Formula	C12H13ClO2
CAS No.	866028-26-4

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 10 mg/mL (44.51 mM)

References and Literature

1. Cocco M, et al. J Med Chem. 2017, 60(9):3656-3671.

Related compound libraries

This product is contained In the following compound libraries：

Highly Selective Inhibitor Library Inhibitor Library Bioactive Compound Library Anti-Breast Cancer Compound Library Nonsteroidal Anti-Inflammatory Compound Library Antidepressant Compound Library Bioactive Compounds Library Max Anti-Liver Cancer Compound Library Anti-Prostate Cancer Compound Library HIF-1 Signaling Pathway Compound Library

Related Products

Related compounds with same targets

D359-0396 Trimethylamine N-oxide NLRP3 agonist 1 NLRP3-IN-23 CORM-3 Arglabin Stavudine INF200

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

INF39 866028-26-4 Immunology/Inflammation NF-Κb NOD-like Receptor (NLR) NOD inhibit INF 39 INF-39 Inhibitor inhibitor

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.