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IPN60090

Catalog No. T11412Cas No. 1853164-83-6
Alias GLS1-IN-1

IPN60090 is a novel, potent, orally bioavailable, renal-type glutaminase (GLS1)-specific inhibitor with an IC50 value of 31 nM for GLS1. IPN60090 has potential anticancer and immunostimulant/immunomodulatory activity, selectively targets, binds, and inhibits human glutaminase, and can be used to study GLS1-mediated diseases.

IPN60090

IPN60090

Purity: 100%
Catalog No. T11412Alias GLS1-IN-1Cas No. 1853164-83-6
IPN60090 is a novel, potent, orally bioavailable, renal-type glutaminase (GLS1)-specific inhibitor with an IC50 value of 31 nM for GLS1. IPN60090 has potential anticancer and immunostimulant/immunomodulatory activity, selectively targets, binds, and inhibits human glutaminase, and can be used to study GLS1-mediated diseases.
Pack SizePriceAvailabilityQuantity
1 mg$107In Stock
5 mg$263In Stock
10 mg$413In Stock
25 mg$668In Stock
50 mg$993In Stock
100 mg$1,320In Stock
1 mL x 10 mM (in DMSO)$297In Stock
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Purity:100%
ee:100%
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Product Introduction

Bioactivity
Description
IPN60090 is a novel, potent, orally bioavailable, renal-type glutaminase (GLS1)-specific inhibitor with an IC50 value of 31 nM for GLS1. IPN60090 has potential anticancer and immunostimulant/immunomodulatory activity, selectively targets, binds, and inhibits human glutaminase, and can be used to study GLS1-mediated diseases.
Targets&IC50
GLS1:31 nM (IC50)
In vitro
IPN60090 has an IC50 against GLS1 and an EC50 against A549 cell proliferation of <100 nM.[1]
In vivo
IPN-60090 (100 mg/kg; oral administration; twice daily; 30 days;) causes tumor growth inhibition. IPN-60090 is robust in vivo target engagement in a dose-dependent manner. The glutamate/glutamine ratios and the free plasma concentrations of IPN-60090 at 4 hours post-dose on both day 4 and day 28 are all decreased.[2]
IPN60090 (3 mg/kg; i.v.; 10 mg/kg for p.o.) has excellent pharmacokinetic properties, with CL=4.1 mL/min/kg, t1/2=1 hour, Cmax=19 μM, F%=89%.[2]
AliasGLS1-IN-1
Chemical Properties
Molecular Weight532.52
FormulaC24H27F3N8O3
Cas No.1853164-83-6
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 27.5 mg/mL (51.64 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM1.8779 mL9.3893 mL18.7786 mL93.8932 mL
5 mM0.3756 mL1.8779 mL3.7557 mL18.7786 mL
10 mM0.1878 mL0.9389 mL1.8779 mL9.3893 mL
20 mM0.0939 mL0.4695 mL0.9389 mL4.6947 mL
50 mM0.0376 mL0.1878 mL0.3756 mL1.8779 mL

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