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IPN60090

IPN60090
IPN60090 is a novel, potent, orally bioavailable, renal-type glutaminase (GLS1)-specific inhibitor with an IC50 value of 31 nM for GLS1. IPN60090 has potential anticancer and immunostimulant/immunomodulatory activity, selectively targets, binds, and inhibits human glutaminase, and can be used to study GLS1-mediated diseases.
Catalog No. T11412Cas No. 1853164-83-6
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Purity:100%
ee:100%
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IPN60090

Purity: 100%
Catalog No. T11412Alias GLS1-IN-1Cas No. 1853164-83-6

IPN60090 is a novel, potent, orally bioavailable, renal-type glutaminase (GLS1)-specific inhibitor with an IC50 value of 31 nM for GLS1. IPN60090 has potential anticancer and immunostimulant/immunomodulatory activity, selectively targets, binds, and inhibits human glutaminase, and can be used to study GLS1-mediated diseases.
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
Pack SizePriceAvailabilityQuantity
1 mg$107In Stock
5 mg$263In Stock
10 mg$413In Stock
25 mg$668In Stock
50 mg$993In Stock
100 mg$1,320In Stock
1 mL x 10 mM (in DMSO)$297In Stock
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Product Introduction

Bioactivity
Description
IPN60090 is a novel, potent, orally bioavailable, renal-type glutaminase (GLS1)-specific inhibitor with an IC50 value of 31 nM for GLS1. IPN60090 has potential anticancer and immunostimulant/immunomodulatory activity, selectively targets, binds, and inhibits human glutaminase, and can be used to study GLS1-mediated diseases.
Targets&IC50
GLS1:31 nM (IC50)
In vitro
IPN60090 has an IC50 against GLS1 and an EC50 against A549 cell proliferation of <100 nM.[1]
In vivo
IPN-60090 (100 mg/kg; oral administration; twice daily; 30 days;) causes tumor growth inhibition. IPN-60090 is robust in vivo target engagement in a dose-dependent manner. The glutamate/glutamine ratios and the free plasma concentrations of IPN-60090 at 4 hours post-dose on both day 4 and day 28 are all decreased.[2]
IPN60090 (3 mg/kg; i.v.; 10 mg/kg for p.o.) has excellent pharmacokinetic properties, with CL=4.1 mL/min/kg, t1/2=1 hour, Cmax=19 μM, F%=89%.[2]
AliasGLS1-IN-1
Chemical Properties
Molecular Weight532.52
FormulaC24H27F3N8O3
Cas No.1853164-83-6
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 27.5 mg/mL (51.64 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM1.8779 mL9.3893 mL18.7786 mL93.8932 mL
5 mM0.3756 mL1.8779 mL3.7557 mL18.7786 mL
10 mM0.1878 mL0.9389 mL1.8779 mL9.3893 mL
20 mM0.0939 mL0.4695 mL0.9389 mL4.6947 mL
50 mM0.0376 mL0.1878 mL0.3756 mL1.8779 mL

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